ArticleAIDS (London, England)2014
HIV-1 subtype C is not associated with higher risk of heterosexual HIV-1 transmission: a multinational study among HIV-1 serodiscordant couples.
Article in AIDS (London, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- HIV-1 subtype C predicted co-receptor tropism in Africa: an individual sequence level meta-analysis.AIDS research and therapy · 2020Pooled it
- Associations between schistosomiasis and HIV-1 acquisition risk in four prospective cohorts: a nested case-control analysis.Journal of the International AIDS Society · 2020Article
- Understanding the mechanisms driving the spread of subtype C HIV-1.EBioMedicine · 2020Review
- Control of the HIV-1 Load Varies by Viral Subtype in a Large Cohort of African Adults With Incident HIV-1 Infection.The Journal of infectious diseases · 2019Article
- Weighing the Evidence of Efficacy of Oral PrEP for HIV Prevention in Women in Southern Africa.AIDS research and human retroviruses · 2018Review
- In vitro functional assessment of natural HIV-1 group M Vpu sequences using a universal priming approach.Journal of virological methods · 2017Article
- Factors Driving the HIV Epidemic in Southern Africa.Current HIV/AIDS reports · 2016Review
- Southern Africa: the Highest Priority Region for HIV Prevention and Care Interventions.Current HIV/AIDS reports · 2015Article
- Variants in host viral replication cycle genes are associated with heterosexual HIV-1 acquisition in Africans.Journal of acquired immune deficiency syndromes (1999) · 2014Article
- Reply to Neogi et al.The Journal of infectious diseases · 2013Article
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Authors and funding
13 authors.
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Abstract
backgroundHIV-1 subtype C has emerged as the most prevalent strain of HIV-1 worldwide, leading to speculation that subtype C may be more transmissible than other subtypes. We compared the risk of HIV-1 transmission for subtype C versus non-C subtypes (A, D, G and recombinant forms) among heterosexual African HIV-1 serodiscordant couples.
methodsWe conducted a nested case-control analysis using data from two prospective cohort studies of heterosexual HIV-1 serodiscordant couples from six countries in eastern and southern Africa. Cases (N = 121) included incident HIV-1 transmissions that were established as linked within the serodiscordant partnership by viral sequencing; controls (N = 501) were nontransmitting HIV-1-infected partners. Subtype was determined for partial env and gag genes. Multiple logistic regression controlled for age and gender of the HIV-1-nfected partner and self-reported unprotected sex. Plasma and genital HIV-1 RNA concentrations were compared between subtype C and non-C subtypes using generalized estimating equations.
resultsHIV-1 subtype C was not associated with increased risk of HIV-1 transmission compared with non-C subtypes: env adjusted odds ratio (adjOR) 1.14 [95% confidence interval (CI) 0.74-1.75, P = 0.6] and gag adjOR 0.98 (95% CI 0.63-1.52, P = 0.9). Plasma and genital HIV-1 RNA levels did not differ significantly for subtype C versus non-C.
conclusionIn a geographically diverse population of heterosexual African HIV-1 serodiscordant couples, subtype C was not associated with greater risk of HIV-1 transmission compared with non-C subtypes, arguing against the hypothesis that subtype C is more transmissible compared with other common subtypes.
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