ArticleCell death and differentiation2014
Lats2 is critical for the pluripotency and proper differentiation of stem cells.
Article in Cell death and differentiation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- NF2 is Essential for Human Endoderm Development.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Role of YAP in hematopoietic differentiation and erythroid lineage specification of human-induced pluripotent stem cells.Stem cell research & therapy · 2023Article
- The Hippo kinase LATS2 impairs pancreatic β-cell survival in diabetes through the mTORC1-autophagy axis.Nature communications · 2021Article
- Protein-protein interaction analysis reveals a novel cancer stem cell related target TMEM17 in colorectal cancer.Cancer cell international · 2021Article
- Genetic screening for single-cell variability modulators driving therapy resistance.Nature genetics · 2021Article
- POPX2 is a novel LATS phosphatase that regulates the Hippo pathway.Oncotarget · 2019Article
- LATS1/2 kinases trigger self-renewal of cancer stem cells in aggressive oral cancer.Oncotarget · 2019Article
- WW Domain-Containing Proteins YAP and TAZ in the Hippo Pathway as Key Regulators in Stemness Maintenance, Tissue Homeostasis, and Tumorigenesis.Frontiers in oncology · 2019Review
- p53 shades of Hippo.Cell death and differentiation · 2018Review
- Article
- The LATS1 and LATS2 tumor suppressors: beyond the Hippo pathway.Cell death and differentiation · 2017Review
- Mutant p53 Protein and the Hippo Transducers YAP and TAZ: A Critical Oncogenic Node in Human Cancers.International journal of molecular sciences · 2017Review
- The Hippo pathway in tissue homeostasis and regeneration.Protein & cell · 2017Review
- The Hippo pathway, p53 and cholesterol.Cell cycle (Georgetown, Tex.) · 2016Review
- Human pluripotent stem cell culture density modulates YAP signaling.Biotechnology journal · 2016Article
- The LATS2 tumor suppressor inhibits SREBP and suppresses hepatic cholesterol accumulation.Genes & development · 2016Article
- LATS2 Positively Regulates Polycomb Repressive Complex 2.PloS one · 2016Article
- Neuroblastoma: oncogenic mechanisms and therapeutic exploitation of necroptosis.Cell death & disease · 2015Review
- Down-regulation of LATS kinases alters p53 to promote cell migration.Genes & development · 2015Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Differentiation is a highly controlled process essential for embryonic and adult development. Moreover, disruption of proper differentiation is often associated with human diseases, including cancer. We analyzed the involvement of the tumor-suppressor Lats2 in mouse embryonic stem cell (mESC) pluripotency and differentiation, and report that mESCs lacking Lats2 are unable to sustain stemness and are not able to initiate and coordinate developmental transcriptional programs. Lats2-/- mESCs retain bivalent 'poised' chromatin marks on developmental genes and exhibit germ layer ambiguity both in vitro and in vivo. Importantly, in coordinating proper germ layer specification, Lats2 engages in a feedback loop with another tumor suppressor, p53.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.