Evidence map›Paper›PMID 24413039›Full record

ArticleJournal of acquired immune deficiency syndromes (1999)2014

Transmitted drug resistance and antiretroviral treatment outcomes in non-subtype B HIV-1-infected patients in South East Asia.

Praphan Phanuphak, Sunee Sirivichayakul, Awachana Jiamsakul, Somnuek Sungkanuparph, Nagalingeswaran Kumarasamy, Man Po Lee, Thira Sirisanthana, Pacharee Kantipong, Christopher Lee, Adeeba Kamarulzaman and 6 more

Abstract read
In one paragraph

Article in Journal of acquired immune deficiency syndromes (1999), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Observational
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Praphan Phanuphak*HIV-NAT, Thai Red Cross AIDS Research Centre, Bangkok, Thailand; †Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; ‡The Kirby Institute, Faculty of Medicine, University of New South Wales, Sydney, Australia; §Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; ‖YRG Centre for AIDS Research and Education, Chennai, India; ¶Queen Elizabeth Hospital, Hong Kong, China; #Research Institute for Health Sciences, Chiang Mai University, Chiang Mai, Thailand; **Chiangrai Prachanukroh Hospital, Chiang Rai, Thailand; ††Hospital Sungai Buloh, Kuala Lumpur, Malaysia; ‡‡University of Malaya, Kuala Lumpur, Malaysia; §§Hospital Raja Perempuan Zainab II, Kota Bharu, Malaysia; ‖‖Research Institute for Tropical Medicine, Manila, Philippines; ¶¶Faculty of Medicine, Udayana University and Sanglah Hospital, Bali, Indonesia; ##Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand; ***TREAT Asia, amfAR-The Foundation for AIDS Research, Bangkok, Thailand; and †††Brown University Alpert Medical School, Providence, RI.
Sunee Sirivichayakul
Awachana Jiamsakul
Somnuek Sungkanuparph
Nagalingeswaran Kumarasamy
Man Po Lee
Thira Sirisanthana
Pacharee Kantipong
Christopher Lee
Adeeba Kamarulzaman
Mahiran Mustafa
Rossana Ditangco
Tuti Merati
Winai Ratanasuwan
Thida Singtoroj
Rami Kantor

Funding

The Asia-Pacific HIV Research CollaborationU01AI069907 · NIAID · FOUNDATION FOR AIDS RESEARCH · PI ANNETTE H SOHN · 2006 to 2026
$44.8M
NIAID NIH HHS U01 AI069907NIAID NIH HHS U01AI069907
6 · The paper itself

Abstract

backgroundWe compared treatment outcomes of transmitted drug resistance (TDR) in patients on fully or partially sensitive drug regimens.

methodsFactors associated with survival and failure were analyzed using Cox proportional hazards and discrete time conditional logistic models.

resultsTDR, found in 60 (4.1%) of 1471 Asian treatment-naive patients, was one of the significant predictors of failure. Patients with TDR to >1 drug in their regimen were >3 times as likely to fail compared to no TDR.

conclusionsTDR was associated with failure in the context of non-fully sensitive regimens. Efforts are needed to incorporate resistance testing into national treatment programs.

Indexed as

Drug Resistance, ViralAdultAnti-Retroviral AgentsAsia, SoutheasternFemaleHIV-1HIV InfectionsHumansMaleMiddle AgedTreatment OutcomeAnti-Retroviral Agents

Identifiers

PMID24413039
PMCPMC4074771

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.