ArticleNature medicine2014
A technique for in vivo mapping of myocardial creatine kinase metabolism.
Article in Nature medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 124 papers.
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Who cites it
124 citing papers in PubMed, 197 citations in OpenAlex.
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- Reliability of In Vivo Creatine-Weighted Chemical Exchange Saturation Transfer (CrCEST) MRI in Calf Skeletal Muscle of Healthy Volunteers at 3 T.Journal of magnetic resonance imaging : JMRI · 2025Article
- Simultaneous monitoring of glycogen, creatine, and phosphocreatine in type II glycogen storage disease using saturation transfer MRI.Magnetic resonance in medicine · 2025Article
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- Mitochondrial oxidative phosphorylation capacity in skeletal muscle measured by ultrafast Z-spectroscopy (UFZ) MRI at 3T.Magnetic resonance in medicine · 2025Article
- Motion and magnetic field inhomogeneity correction techniques for chemical exchange saturation transfer (CEST) MRI: A contemporary review.NMR in biomedicine · 2025Review
- Plasma metabolomic characteristics of atrial fibrillation patients with spontaneous echo contrast.BMC cardiovascular disorders · 2024Article
- Reproducibility of 3D chemical exchange saturation transfer (CEST) contrasts in the healthy brain at 3T.Scientific reports · 2024Article
- Non-invasive mapping of brown adipose tissue activity with magnetic resonance imaging.Nature metabolism · 2024Article
- Quasi-steady-state (QUASS) reconstruction enhances TMagnetic resonance in medicine · 2024Article
- Personalized and muscle-specific OXPHOS measurement with integrated CrCEST MRI and proton MR spectroscopy.Nature communications · 2024Article
64 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
16 authors at 2 institutions in 1 country.
Funding
Abstract
ATP derived from the conversion of phosphocreatine to creatine by creatine kinase provides an essential chemical energy source that governs myocardial contraction. Here, we demonstrate that the exchange of amine protons from creatine with protons in bulk water can be exploited to image creatine through chemical exchange saturation transfer (CrEST) in myocardial tissue. We show that CrEST provides about two orders of magnitude higher sensitivity compared to (1)H magnetic resonance spectroscopy. Results of CrEST studies from ex vivo myocardial tissue strongly correlate with results from (1)H and (31)P magnetic resonance spectroscopy and biochemical analysis. We demonstrate the feasibility of CrEST measurement in healthy and infarcted myocardium in animal models in vivo on a 3-T clinical scanner. As proof of principle, we show the conversion of phosphocreatine to creatine by spatiotemporal mapping of creatine changes in the exercised human calf muscle. We also discuss the potential utility of CrEST in studying myocardial disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.