ArticleBrain, behavior, and immunity2014
The role of IL-1β and TNF-α signaling in the genesis of cancer treatment related symptoms (CTRS): a study using cytokine receptor-deficient mice.
Article in Brain, behavior, and immunity, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 39 citations in OpenAlex.
- Cytokine-Cytokine Receptor Interaction and Endocytosis are Common Pathways for Symptom Burden and Sickness Behavior Symptoms in Oncology Patients Undergoing Chemotherapy.Cancer medicine · 2025Article
- Comprehensive review of mouse models for studying cancer-related fatigue: Methods, findings and future directions (Review).Experimental and therapeutic medicine · 2025Review
- Exercise and inflammatory cytokine regulation among older adults with myeloid malignancies.Experimental gerontology · 2024Article
- Microglia are implicated in the development of paclitaxel chemotherapy-associated cognitive impairment in female mice.Brain, behavior, and immunity · 2023Article
- Protocol for a pilot randomized controlled trial of a mobile health exercise intervention for older patients with myeloid neoplasms (GO-EXCAP 2).Journal of geriatric oncology · 2022Article
- Paclitaxel chemotherapy disrupts behavioral and molecular circadian clocks in mice.Brain, behavior, and immunity · 2022Article
- Social enrichment attenuates chemotherapy induced pro-inflammatory cytokine production and affective behavior via oxytocin signaling.Brain, behavior, and immunity · 2020Article
- Cytotoxic Therapy-Induced Effects on Both Hematopoietic and Marrow Stromal Cells Promotes Therapy-Related Myeloid Neoplasms.Blood cancer discovery · 2020Article
- [Research Progress of Cancer-associated Fibroblasts in Lung Cancer].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2020Review
- The Antiemetic Effect of Xiao-Ban-Xia-Tang Formula against Cisplatin-Induced Emesis is Mediated through Inhibition of NLRP3 Inflammasome Activation in a Rat Pica Model.Evidence-based complementary and alternative medicine : eCAM · 2020Article
- Activation of orexinergic and histaminergic pathway involved in therapeutic effect of histamine HNaunyn-Schmiedeberg's archives of pharmacology · 2019Article
- Gut microbiota-immune-brain interactions in chemotherapy-associated behavioral comorbidities.Cancer · 2018Review
- Interleukin-1 Beta-A Friend or Foe in Malignancies?International journal of molecular sciences · 2018Review
- Protocol for Exercise Program in Cancer and Cognition (EPICC): A randomized controlled trial of the effects of aerobic exercise on cognitive function in postmenopausal women with breast cancer receiving aromatase inhibitor therapy.Contemporary clinical trials · 2018Article
- Effort but not Reward Sensitivity is Altered by Acute Sickness Induced by Experimental Endotoxemia in Humans.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- Dexamethasone exacerbates cytotoxic chemotherapy induced lethargy and weight loss in female tumor free mice.Cancer biology & therapy · 2018Article
- Neuroimmunology of Behavioral Comorbidities Associated With Cancer and Cancer Treatments.Frontiers in immunology · 2018Review
- Time-of-Day Dictates Transcriptional Inflammatory Responses to Cytotoxic Chemotherapy.Scientific reports · 2017Article
- Interleukin-1 as a mediator of fatigue in disease: a narrative review.Journal of neuroinflammation · 2017Review
- The problem of fatigue in patients suffering from neoplastic disease.Contemporary oncology (Poznan, Poland) · 2017Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Cytotoxic chemotherapeutic agents often induce a cluster of cancer treatment related symptoms (CTRS). The purpose of this study was to develop a mouse model of CTRS to examine the role of IL-1β and TNF-α signaling in the genesis of these symptoms. CTRS (change in wheel running activity, food intake, and body weight from baseline) were examined in wild type (WT) mice or mice lacking the TNF-α p55 (type 1) receptor (TNFR1-/-) and/or IL-1β type 1 receptor (IL-1R1-/-) injected with four doses of cyclophosphamide/Adriamycin/5-fluorouracil (CAF) at 20-day intervals. Inflammatory cytokines in blood and tissues were measured using multiplex immunoassays and quantitative RT-PCR. ANOVA was used to examine differences between genotype and/or treatment group. Kaplan-Meier analysis was used to estimate survival rate. CAF rapidly increased IL-1β and TNF-α signaling in WT mice. CAF induced acute CTRS immediately following drug injection which returned to baseline prior to the next CAF dose. Persistent CTRS were evident 3weeks after the 4th CAF dose. Acute but not persistent CTRS were associated with increased levels of IL-7, IL-9, KC, MCP-1, GCSF, and IP-10. This CAF induced inflammatory response was blunted in IL-1R1 deficient mice and absent in IL-1R1/TNFR1-deficient mice. IL-1R1-/- mice showed an identical pattern of CTRS to their WT counterparts. The assessment of CTRS in IL-1R1/TNF-R1-deficient mice was precluded by severe toxicity. Our data suggest that an important function of the IL-1β and TNF-α driven inflammatory cascade is to promote recovery following exposure to cytotoxic agents.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.