ReviewAutonomic neuroscience : basic & clinical2014
Role of enteric neurotransmission in host defense and protection of the gastrointestinal tract.
Review in Autonomic neuroscience : basic & clinical, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
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- Diabetes-Associated Neuroplastic Changes in Neuropeptide Y-Immunoreactive Enteric Neurons Along the Porcine Gastrointestinal Tract.International journal of molecular sciences · 2026Article
- Enteric neuropathy and the vagus nerve: Therapeutic implications.Neurogastroenterology and motility · 2025Review
- Neuroimmune interactions: The bridge between inflammatory bowel disease and the gut microbiota.Clinical and translational medicine · 2025Review
- Impact of gut health and microbiome on autism spectrum disorder.Translational pediatrics · 2024Article
- The Coding Logic of Interoception.Annual review of physiology · 2024Review
- Gut/rumen-mammary gland axis in mastitis: Gut/rumen microbiota-mediated "gastroenterogenic mastitis".Journal of advanced research · 2024Article
- Is obesity the next step in evolution through brain changes?Neuroscience applied · 2024Article
- The enteric nervous system.Physiological reviews · 2023Review
- Article
- Anti-inflammatory effects of vagal nerve stimulation with a special attention to intestinal barrier dysfunction.Neurogastroenterology and motility · 2022Review
- Immunofluorescence Staining of P2X7 Receptors in Whole-Mount Myenteric Plexus Preparations.Methods in molecular biology (Clifton, N.J.) · 2022Article
- The enteric nervous system in gastrointestinal disease etiology.Cellular and molecular life sciences : CMLS · 2021Review
- Faecal Transplantation, Pro- and Prebiotics in Parkinson's Disease; Hope or Hype?Journal of Parkinson's disease · 2019Review
- Neuroimmunophysiology of the gut: advances and emerging concepts focusing on the epithelium.Nature reviews. Gastroenterology & hepatology · 2018Review
- Hirschsprung disease - integrating basic science and clinical medicine to improve outcomes.Nature reviews. Gastroenterology & hepatology · 2018Review
- The Gut Microbiome Feelings of the Brain: A Perspective for Non-Microbiologists.Microorganisms · 2017Review
- Sensory neuron regulation of gastrointestinal inflammation and bacterial host defence.Journal of internal medicine · 2017Review
- Gut Microbiota in Cardiovascular Health and Disease.Circulation research · 2017Review
- Toll-Like Receptor 4 Modulates Small Intestine Neuromuscular Function through Nitrergic and Purinergic Pathways.Frontiers in pharmacology · 2017Article
Corrections and comments
- Reprinted as
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Host defense is a vital role played by the gastrointestinal tract. As host to an enormous and diverse microbiome, the gut has evolved an elaborate array of chemical and physicals barriers that allow the digestion and absorption of nutrients without compromising the mammalian host. The control of such barrier functions requires the integration of neural, humoral, paracrine and immune signaling, involving redundant and overlapping mechanisms to ensure, under most circumstances, the integrity of the gastrointestinal epithelial barrier. Here we focus on selected recent developments in the autonomic neural control of host defense functions used in the protection of the gut from luminal agents, and discuss how the microbiota may potentially play a role in enteric neurotransmission. Key recent findings include: the important role played by subepithelial enteric glia in modulating intestinal barrier function, identification of stress-induced mechanisms evoking barrier breakdown, neural regulation of epithelial cell proliferation, the role of afferent and efferent vagal pathways in regulating barrier function, direct evidence for bacterial communication to the enteric nervous system, and microbial sources of enteric neurotransmitters. We discuss these new and interesting developments in our understanding of the role of the autonomic nervous system in gastrointestinal host defense.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.