ReviewBiotechnology advances
Advances in repairing the degenerate retina by rod photoreceptor transplantation.
Review in Biotechnology advances. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 50 citations in OpenAlex.
- Congenital Stationary Night Blindness: Clinical and Genetic Features.International journal of molecular sciences · 2022Article
- Light microscopic evidence of in vivo differentiation from the transplanted inferior turbinate-derived stem cell into the rod photoreceptor in degenerating retina of the mouse.Applied microscopy · 2020Article
- Retinal Tissue Bioengineering, Materials and Methods for the Treatment of Glaucoma.Tissue engineering and regenerative medicine · 2020Review
- Pluripotent Stem Cells as Models of Retina Development.Molecular neurobiology · 2019Review
- Transplantation of rat embryonic stem cell-derived retinal cells restores visual function in the Royal College of Surgeons rats.Documenta ophthalmologica. Advances in ophthalmology · 2018Article
- Transplanted hESC-Derived Retina Organoid Sheets Differentiate, Integrate, and Improve Visual Function in Retinal Degenerate Rats.Investigative ophthalmology & visual science · 2018Article
- Transplanted Donor- or Stem Cell-Derived Cone Photoreceptors Can Both Integrate and Undergo Material Transfer in an Environment-Dependent Manner.Stem cell reports · 2018Article
- Cell-based therapeutic strategies for replacement and preservation in retinal degenerative diseases.Progress in retinal and eye research · 2017Review
- Deafferented Adult Rod Bipolar Cells Create New Synapses with Photoreceptors to Restore Vision.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Neurotransmitter-Regulated Regeneration in the Zebrafish Retina.Stem cell reports · 2017Article
- Experimental Study of the Biological Properties of Human Embryonic Stem Cell-Derived Retinal Progenitor Cells.Scientific reports · 2017Article
- Grafted c-kitStem cell research & therapy · 2016Article
- Donor and host photoreceptors engage in material transfer following transplantation of post-mitotic photoreceptor precursors.Nature communications · 2016Article
- Seasonal and post-trauma remodeling in cone-dominant ground squirrel retina.Experimental eye research · 2016Review
- Efficacy and Safety of Human Retinal Progenitor Cells.Translational vision science & technology · 2016Article
- Transplanted neurons integrate into adult retinas and respond to light.Nature communications · 2016Article
- Report on the National Eye Institute Audacious Goals Initiative: Photoreceptor Regeneration and Integration Workshop.Translational vision science & technology · 2015Article
- Transplantation of Human Neural Progenitor Cells Expressing IGF-1 Enhances Retinal Ganglion Cell Survival.PloS one · 2015Article
- Chapter 8 - Restoring Vision to the Blind: Evaluating Visual Function, Endpoints.Translational vision science & technology · 2014Article
- Chapter 4 - Restoring Vision to the Blind: Stem Cells and Transplantation.Translational vision science & technology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Despite very different aetiologies, age-related macular degeneration (AMD) and most inherited retinal disorders culminate in the same final common pathway, loss of the light-sensitive photoreceptors. There are few clinical treatments and none can reverse the loss of vision. Photoreceptor replacement by transplantation is proposed as a broad treatment strategy applicable to all degenerations. The past decade has seen a number of landmark achievements in this field, which together provide strong justification for continuing investigation into photoreceptor replacement strategies. These include proof of principle for restoring vision by rod-photoreceptor transplantation in mice with congenital stationary night blindness and advances in stem cell biology, which have led to the generation of complete optic structures in vitro from embryonic stem cells. The latter represents enormous potential for generating suitable and renewable donor cells with which to achieve the former. However, there are still challenges presented by the degenerating recipient retinal environment that must be addressed as we move to translating these technologies towards clinical application.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.