Evidence map›Paper›PMID 24412338›Full record

ArticleBioorganic & medicinal chemistry2014

Chemoenzymatic synthesis of ADP-d-glycero-β-d-manno-heptose and study of the substrate specificity of HldE.

Tiehai Li, Liuqing Wen, Adriel Williams, Baolin Wu, Lei Li, Jingyao Qu, Jeffrey Meisner, Zhongying Xiao, Junqiang Fang, Peng George Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioorganic & medicinal chemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Synthetic Optimizations for Gram-Scale Preparation of 1-Molecules (Basel, Switzerland) · 2022
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tiehai LiDepartment of Chemistry, Center for Therapeutics and Diagnostics, Georgia State University, Atlanta, GA 30303, USA.
Liuqing WenDepartment of Chemistry, Center for Therapeutics and Diagnostics, Georgia State University, Atlanta, GA 30303, USA.
Adriel WilliamsDepartment of Chemistry, Center for Therapeutics and Diagnostics, Georgia State University, Atlanta, GA 30303, USA.
Baolin WuDepartment of Chemistry, Center for Therapeutics and Diagnostics, Georgia State University, Atlanta, GA 30303, USA.
Lei LiDepartment of Chemistry, Center for Therapeutics and Diagnostics, Georgia State University, Atlanta, GA 30303, USA.
Jingyao QuDepartment of Chemistry, Center for Therapeutics and Diagnostics, Georgia State University, Atlanta, GA 30303, USA.
Jeffrey MeisnerDepartment of Chemistry, Center for Therapeutics and Diagnostics, Georgia State University, Atlanta, GA 30303, USA.
Zhongying XiaoDepartment of Chemistry, Center for Therapeutics and Diagnostics, Georgia State University, Atlanta, GA 30303, USA.
Junqiang FangNational Glycoengineering Research Center, Shandong University, Jinan, Shandong 250100, People's Republic of China.
Peng George WangDepartment of Chemistry, Center for Therapeutics and Diagnostics, Georgia State University, Atlanta, GA 30303, USA; National Glycoengineering Research Center, Shandong University, Jinan, Shandong 250100, People's Republic of China. Electronic address: pwang11@gsu.edu.

Funding

Biosynthesis of PolysaccharidesR01GM085267 · NIGMS · OHIO STATE UNIVERSITY · PI WANG, PENG GEORGE · 2009 to 2017
$2.4M
NIGMS NIH HHS R01 GM085267
6 · The paper itself

Abstract

An efficient one-pot three enzymes strategy for chemoenzymatic synthesis of ADP-d-glycero-β-d-manno-heptose (ADP-d, d-heptose) was reported using chemically synthesized d, d-heptose-7-phosphate and the ADP-d, d-heptose biosynthetic enzymes HldE and GmhB. Moreover, the result of investigating substrate specificity of the kinase action of HldE revealed that HldE had highly restricted substrate specificity towards structurally modified heptose-7-phosphate analogs.

Indexed as

Adenosine Diphosphate SugarsChemistry Techniques, SyntheticMultienzyme ComplexesNucleotidyltransferasesPhosphotransferases (Alcohol Group Acceptor)Substrate SpecificitySugar PhosphatesAdenosine Diphosphate SugarsD,D heptose 7-phosphate kinase-D,D-heptose 1-phosphate adenylyltransferase, E coliMultienzyme ComplexesNucleotidyltransferasesPhosphotransferases (Alcohol Group Acceptor)Sugar PhosphatesAnalogsChemoenzymaticSpecificitySynthesis

Identifiers

PMID24412338
PMCPMC3976583

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.