ArticleBehavioural processes2014
Behaviourally inhibited temperament and female sex, two vulnerability factors for anxiety disorders, facilitate conditioned avoidance (also) in humans.
Article in Behavioural processes, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 54 citations in OpenAlex.
- Exaggerated acquisition and resistance to extinction of avoidance behavior in treated heroin-dependent men.The Journal of clinical psychiatry · 2016Trial
- Methamphetamine increases risky choice in rats, but only when magnitude and probability of reinforcement are manipulated within a session.Pharmacology, biochemistry, and behavior · 2024Article
- Activation patterns in male and female forebrain circuitries during food consumption under novelty.Brain structure & function · 2024Article
- Societal influence and psychological distress among Indonesian adults in Java on the early Omicron wave of COVID-19.Future science OA · 2023Article
- Weaker situations: Uncertainty reveals individual differences in learning: Implications for PTSD.Cognitive, affective & behavioral neuroscience · 2023Review
- Behavioral Management as a Coping Strategy for Managing Stressors in Primates: The Influence of Temperament and Species.Biology · 2022Article
- Relationship between behavioral inhibition/activation system and Internet addiction among Chinese college students: The mediating effects of intolerance of uncertainty and self-control and gender differences.Frontiers in public health · 2022Article
- Developmental associations between risk-taking and anxiety symptoms across ages 8-12 years.Child development · 2021Article
- Sex differences in specific aspects of two animal tests of anxiety-like behavior.Psychopharmacology · 2021Article
- Sex differences in neural responses to reward and the influences of individual reward and punishment sensitivity.BMC neuroscience · 2021Article
- Behavioral Inhibition/Activation Systems and Depression Among Females With Substance Use Disorder: The Mediating Role of Intolerance of Uncertainty and Anhedonia.Frontiers in psychiatry · 2021Article
- A reinforcement-learning model of active avoidance behavior: Differences between Sprague Dawley and Wistar-Kyoto rats.Behavioural brain research · 2020Article
- The effects of novelty on food consumption in male and female rats.Physiology & behavior · 2020Article
- Predictors of risky foraging behaviour in healthy young people.Nature human behaviour · 2020Article
- Maladaptive avoidance patterns in Parkinson's disease are exacerbated by symptoms of depression.Behavioural brain research · 2020Article
- A parent-report scale of behavioral inhibition: Validation and application to preschool-age children who do and do not stutter.Journal of fluency disorders · 2020Article
- Cardiorespiratory Response to Moderate Hypercapnia in Female College Students Expressing Behaviorally Inhibited Temperament.Frontiers in neuroscience · 2020Article
- Renewal of fear and avoidance in humans to escalating threat: Implications for translational research on anxiety disorders.Journal of the experimental analysis of behavior · 2020Article
- Sex differences in reward- and punishment-guided actions.Cognitive, affective & behavioral neuroscience · 2019Article
- Inhibited Personality Temperaments Translated Through Enhanced Avoidance and Associative Learning Increase Vulnerability for PTSD.Frontiers in psychology · 2019Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Acquisition and maintenance of avoidance behaviour is a key feature of all human anxiety disorders. Animal models have been useful in understanding how anxiety vulnerability could translate into avoidance learning. For example, behaviourally inhibited temperament and female sex, two vulnerability factors for clinical anxiety, are associated with faster acquisition of avoidance responses in rodents. However, to date, the translation of such empirical data to human populations has been limited since many features of animal avoidance paradigms are not typically captured in human research. Here, using a computer-based task that captures many features of rodent escape-avoidance learning paradigms, we investigated whether avoidance learning would be faster in humans with inhibited temperament and/or female sex and, if so, whether this facilitation would take the same form. Results showed that, as in rats, both vulnerability factors were associated with facilitated acquisition of avoidance behaviour in humans. Specifically, inhibited temperament was associated with higher rate of avoidance responding, while female sex was associated with longer avoidance duration. These findings strengthen the direct link between animal avoidance work and human anxiety vulnerability, further motivating the study of animal models while also providing a simple testbed for a direct human testing.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.