Evidence map›Paper›PMID 24412227›Full record

ArticleBiological psychology2014

Increased insula coactivation with salience networks in insomnia.

Michael C Chen, Catie Chang, Gary H Glover, Ian H Gotlib

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biological psychology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

84 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  4. Examining fronto-limbic brain and sleep mechanisms of antidepressant effects in cognitive-behavioral therapy for insomnia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
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24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Michael C ChenDepartment of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, United States; Department of Psychology, Stanford University, Stanford, CA 94305, United States. Electronic address: mcchen@alumni.stanford.edu.
Catie ChangAdvanced MRI Section, Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States; Department of Electrical Engineering, Stanford University, Stanford, CA 94305, United States; Department of Radiology, Stanford University, Stanford, CA 94305, United States.
Gary H GloverDepartment of Electrical Engineering, Stanford University, Stanford, CA 94305, United States; Department of Radiology, Stanford University, Stanford, CA 94305, United States.
Ian H GotlibDepartment of Psychology, Stanford University, Stanford, CA 94305, United States.

Funding

Training in Psychopathology and Affective ScienceT32MH019956 · NIMH · STANFORD UNIVERSITY · PI GOTLIB, IAN H · 1995 to 2014
$2.1M
Interpretation Bias Training in Depressed Adolescents: Effects and MechanismsR21MH101545 · NIMH · STANFORD UNIVERSITY · PI GOTLIB, IAN H · 2013 to 2014
$432k
NIMH NIH HHS R21 MH101545NIMH NIH HHS T32 MH019956NIMH NIH HHS T32MH019956
6 · The paper itself

Abstract

Insomnia is among the most prevalent and costly of all sleep-related disorders. To characterize the neural mechanisms underlying subjective dysfunction in insomnia, we examined brain activity in 17 female insomniacs and 17 female healthy controls using simultaneous functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) while they were resting and while they were trying to fall asleep. In examining the dynamic regional activity within intrinsic brain networks, we found that, compared with controls, insomniacs had greater involvement of the anterior insula with salience networks, as well as insula BOLD correlation with EEG gamma frequency power during rest in insomniacs. This increased involvement of the anterior insula was associated with negative affect in insomniacs. Aberrant activation of the insula, which integrates temporal and bodily states, in arousal networks may underlie the misperception of sleep quality and subjective distress in insomnia.

Indexed as

AdolescentAdultArousalBrainBrain MappingCerebral CortexDiagnostic and Statistical Manual of Mental DisordersElectroencephalographyFemaleHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingNerve NetNeuropsychological TestsOxygenRestOxygenEEGfMRIInsomniaInsulaResting stateSalience networks

Identifiers

PMID24412227
PMCPMC3961550

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.