Trial reportResuscitation2014
Early coronary angiography and induced hypothermia are associated with survival and functional recovery after out-of-hospital cardiac arrest.
Trial report in Resuscitation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 52 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Resuscitation Outcomes Consortium (ROC) Prehospital Resuscitation Using an Impedance Valve and Early Versus Delayed Analysis
Risk Stratification of Patients Presenting With Cardiac Arrest
Who cites it
52 citing papers in PubMed.
- Association of early withdrawal of life-sustaining therapy for perceived neurological prognosis with mortality after cardiac arrest.Resuscitation · 2016Trial
- [The Cardiac Arrest Receiving Team based on the Freiburg model : Structuring of postresuscitation care following nontraumatic, out-of-hospital cardiac arrest in an interdisciplinary team].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2026Review
- Withdrawal of life-sustaining therapies after cardiac arrest.Current opinion in critical care · 2025Review
- Article
- Mechanisms and treatment of anemia related to cardiac arrest.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2024Review
- Review
- Association of Socioeconomic Status With Long-Term Outcome in Survivors After Out-of-Hospital Cardiac Arrest: Nationwide Population-Based Longitudinal Study.JMIR public health and surveillance · 2023Article
- [Cardiac arrest centers-certification fosters inflow of patients by emergency medical services].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2023Article
- Association of ultra-early diffusion-weighted magnetic resonance imaging with neurological outcomes after out-of-hospital cardiac arrest.Critical care (London, England) · 2023Observational
- Coronary Artery Bypass Grafting in Patients with Acute Myocardial Infarction and Cardiogenic Shock.Reviews in cardiovascular medicine · 2022Article
- In-hospital mode of death after out-of-hospital cardiac arrest.Resuscitation plus · 2022Article
- Article
- Beyond return of spontaneous circulation: update on post-cardiac arrest management in the intensive care unit.Singapore medical journal · 2021Review
- Extracorporeal cardiopulmonary resuscitation for in- and out-of-hospital cardiac arrest: systematic review and meta-analysis of propensity score-matched cohort studies.Journal of the American College of Emergency Physicians open · 2020Article
- Prehospital Double Defibrillation for Refractory Ventricular Fibrillation: A Scoping Review Protocol.The Journal of innovations in cardiac rhythm management · 2020Article
- [Freiburg Cardiac Arrest Receiving Team (CART) : Interdisciplinary solution for the acute management of non-traumatic out-of-hospital cardiac arrest].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2020Article
- Outcome in Patients Resuscitated following Myocardial Infarction with Acute Kidney Injury.International journal of medical sciences · 2020Article
- Contemporary Management of Out-of-hospital Cardiac Arrest in the Cardiac Catheterisation Laboratory: Current Status and Future Directions.Interventional cardiology (London, England) · 2019Review
- Clinical Implication of Coronary Artery Calcium Score in Survivors of Out-of-Hospital Cardiac Arrest.Circulation reports · 2019Article
- Variability in functional outcome and treatment practices by treatment center after out-of-hospital cardiac arrest: analysis of International Cardiac Arrest Registry.Intensive care medicine · 2019Article
Corrections and comments
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Authors and funding
18 authors.
Funding
Abstract
backgroundThe rate and effect of coronary interventions and induced hypothermia after out-of-hospital cardiac arrest (OHCA) are unknown. We measured the association of early (≤24h after arrival) coronary angiography, reperfusion, and induced hypothermia with favorable outcome after OHCA.
methodsWe performed a secondary analysis of a multicenter clinical trial (NCT00394706) conducted between 2007 and 2009 in 10 North American regions. Subjects were adults (≥18 years) hospitalized after OHCA with pulses sustained ≥60min. We measured the association of early coronary catheterization, percutaneous coronary intervention, fibrinolysis, and induced hypothermia with survival to hospital discharge with favorable functional status (modified Rankin Score≤3).
resultsFrom 16,875 OHCA subjects, 3981 (23.6%) arrived at 151 hospitals with sustained pulses. 1317 (33.1%) survived to hospital discharge, with 1006 (25.3%) favorable outcomes. Rates of early coronary catheterization (19.2%), coronary reperfusion (17.7%) or induced hypothermia (39.3%) varied among hospitals, and were higher in hospitals treating more subjects per year. Odds of survival and favorable outcome increased with hospital volume (per 5 subjects/year OR 1.06; 95%CI: 1.04-1.08 and OR 1.06; 95%CI: 1.04, 1.08, respectively). Survival and favorable outcome were independently associated with early coronary angiography (OR 1.69; 95%CI 1.06-2.70 and OR 1.87; 95%CI 1.15-3.04), coronary reperfusion (OR 1.94; 95%CI 1.34-2.82 and OR 2.14; 95%CI 1.46-3.14), and induced hypothermia (OR 1.36; 95%CI 1.01-1.83 and OR 1.42; 95%CI 1.04-1.94).
interpretationEarly coronary intervention and induced hypothermia are associated with favorable outcome and are more frequent in hospitals that treat higher numbers of OHCA subjects per year.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.