ArticleBrain and cognition2014
Social anhedonia and medial prefrontal response to mutual liking in late adolescents.
Article in Brain and cognition, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 36 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Treatment, Emotion, and Neuromodulation of Depression (TREND) Study
Anhedonia, Development, and Emotions: Phenotyping and Therapeutics (ADEPT) Study
Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Social reward processing in depressed and healthy individuals across the lifespan: A systematic review and a preliminary coordinate-based meta-analysis of fMRI studies.Behavioural brain research · 2023Pooled it
- Continuous theta burst stimulation to dorsomedial prefrontal cortex in young adults with depression: Changes in resting frontostriatal functional connectivity relevant to positive mood.Behaviour research and therapy · 2024Trial
- Low Emotional Awareness and Altered Frontostriatal Functional Connectivity During Reward Processing Prospectively Predict Depressive Symptoms in At-Risk Youth.Journal of child and adolescent psychopharmacology · 2026Article
- Striatal social reward sensitivity predicts trust-related brain responses depending on closeness and depression.Biological psychology · 2026Article
- Neural response to reward as a potential pathway from inflammation to anhedonia in adolescents at risk for depression.Brain, behavior, & immunity - health · 2026Article
- Striatal Social Reward Sensitivity Predicts Trust-Related Brain Responses Depending on Closeness and Depression.bioRxiv : the preprint server for biology · 2026Article
- Understanding suicide in sexual minority youth: neural reactivity to social cues as a moderating influence.Cognitive, affective & behavioral neuroscience · 2025Article
- A Systematic Review: Investigating Biomarkers of Anhedonia and Amotivation in Depression and Cannabis Use.JAACAP open · 2025Review
- Momentary state anhedonia is associated with the quantity and quality of daily-life peer experiences among adolescents at varying risk for suicidal thoughts and behaviors.Development and psychopathology · 2025Article
- Weighing the predictive role of neural factors for adolescent anhedonia in the presence of demographic and clinical factors.Journal of mood and anxiety disorders · 2025Article
- Neuroanatomical associations with autistic characteristics in those with acute anorexia nervosa and weight-restored individuals.Psychological medicine · 2025Article
- Longitudinal relationships between social anhedonia and internalizing symptoms in autistic children: results from the Autism Biomarkers Consortium for Clinical Trials.Psychological medicine · 2025Article
- Sleep disturbance and social reward processing as characteristics linking minority victimization and suicidal ideation in youth.Frontiers in neuroscience · 2024Article
- Tensorial independent component analysis reveals social and reward networks associated with major depressive disorder.Human brain mapping · 2023Article
- Splitting the reward: Differences in inflammatory marker associations with neural connectivity between reward anticipation and reward outcome in adolescents at high risk for depression.Journal of affective disorders · 2023Article
- Individual and group format adjunct therapy on social emotional skills for adolescent inpatients with severe and complex eating disorders (CREST-A).Neuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der Gesellschaft Osterreichischer Nervenarzte und Psychiater · 2021Article
- GENETIC AND ENVIRONMENTAL CONTRIBUTIONS TO POSITIVE AFFECT: INSIGHTS FROM ADOLESCENT TWINS.Affective science · 2021Article
- Sleep abnormalities in individuals at clinical high risk for psychosis.Journal of psychiatric research · 2021Article
- A Social Affective Neuroscience Model of Risk and Resilience in Adolescent Depression: Preliminary Evidence and Application to Sexual and Gender Minority Adolescents.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2021Review
- Social reward processing: A biomarker for predicting psychosis risk?Schizophrenia research · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Anhedonia, a cardinal symptom of depression defined as difficulty experiencing pleasure, is also a possible endophenotype and prognostic factor for the development of depression. The onset of depression typically occurs during adolescence, a period in which social status and affiliation are especially salient. The medial prefrontal cortex (mPFC), a region implicated in reward, self-relevant processing, and social cognition, exhibits altered function in adults with anhedonia, but its association with adolescent anhedonia has yet to be investigated. We examined neural response to social reward in 27 late adolescents, 18-21years old, who varied in social anhedonia. Participants reported their social anhedonia, completed ratings of photos of unfamiliar peers, and underwent a functional magnetic resonance imaging task involving feedback about being liked. Adolescents with higher social anhedonia exhibited greater mPFC activation in response to mutual liking (i.e., being liked by someone they also liked) relative to received liking (i.e., being liked by someone whom they did not like). This association held after controlling for severity of current depressive symptoms, although depressive severity was also associated with greater mPFC response. Adolescents with higher levels of social anhedonia also had stronger positive connectivity between the nucleus accumbens and the mPFC during mutual versus received liking. These results, the first on the pathophysiology of adolescent anhedonia, support altered neural reward-circuit response to social reward in young people with social anhedonia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.