Evidence map›Paper›PMID 24411942›Full record

Trial reportCell metabolism2014

β-Aminoisobutyric acid induces browning of white fat and hepatic β-oxidation and is inversely correlated with cardiometabolic risk factors.

Lee D Roberts, Pontus Boström, John F O'Sullivan, Robert T Schinzel, Gregory D Lewis, Andre Dejam, Youn-Kyoung Lee, Melinda J Palma, Sondra Calhoun, Anastasia Georgiadi and 13 more

Open access · bronzeAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Cell metabolism, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 367 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
367citing papers in PubMed, 5 pooled it
25.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

367 citing papers in PubMed, 5 syntheses or guidelines pooled it, 625 citations in OpenAlex.

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  3. New Mediators in the Crosstalk between Different Adipose Tissues.International journal of molecular sciences · 2024
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307 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors at 10 institutions in 4 countries.

Lee D RobertsCardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Pontus BoströmDana-Farber Cancer Institute and Harvard Medical School, 3 Blackfan Circle, CLS Building, Floor 11, Boston, MA 02115, USA; Institutionen för Cell-Och Molekylärbiologi (CMB), Karolinska Institutet, von Eulers väg 3, 171 77 Stockholm, Sweden.
John F O'SullivanCardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Robert T SchinzelCardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Institut für Biologie-Mikrobiologie, Fachbereich Biologie, Chemie, Pharmazie, Freie Universität Berlin, Königin-Luise-Strasse 12-16,14195 Berlin, Germany.
Gregory D LewisCardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Andre DejamCardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Youn-Kyoung LeeCardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
Melinda J PalmaCardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Sondra CalhounDana-Farber Cancer Institute and Harvard Medical School, 3 Blackfan Circle, CLS Building, Floor 11, Boston, MA 02115, USA.
Anastasia GeorgiadiInstitutionen för Cell-Och Molekylärbiologi (CMB), Karolinska Institutet, von Eulers väg 3, 171 77 Stockholm, Sweden.
Ming-Huei ChenFramingham Heart Study of the National Heart, Lung, and Blood Institute and Boston University School of Medicine, Framingham, MA 01702, USA; Department of Neurology, Boston University School of Medicine, Boston, MA 02118, USA; Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA.
Vasan S RamachandranFramingham Heart Study of the National Heart, Lung, and Blood Institute and Boston University School of Medicine, Framingham, MA 01702, USA; Cardiology Section, Boston Medical Center, Boston University School of Medicine, Boston, MA 02118, USA.
Martin G LarsonFramingham Heart Study of the National Heart, Lung, and Blood Institute and Boston University School of Medicine, Framingham, MA 01702, USA; Department of Mathematics and Statistics, Boston University, Boston, MA 02215, USA.
Claude BouchardPennington Biomedical Research Center, Baton Rouge, LA 70808, USA.
Tuomo RankinenPennington Biomedical Research Center, Baton Rouge, LA 70808, USA.
Amanda L SouzaBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Clary B ClishBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Thomas J WangCardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Cardiology Division, Vanderbilt University, Nashville, TN 37232, USA.
Jennifer L EstallInstitut de Recherches Cliniques de Montreal, Montreal, QC H2W 1R7, Canada.
Alexander A SoukasCenter for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Chad A CowanCardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Bruce M SpiegelmanDana-Farber Cancer Institute and Harvard Medical School, 3 Blackfan Circle, CLS Building, Floor 11, Boston, MA 02115, USA.
Robert E GersztenCardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address: rgerszten@partners.org.
Harvard University · USMassachusetts General Hospital · USBroad Institute · USFramingham Heart Study · USKarolinska Institutet · SEPennington Biomedical Research Center · USBoston Medical Center · USDana-Farber Cancer Institute · USMontreal Clinical Research Institute · CAVanderbilt University · US

Funding

Metabolomic predictors of insulin resistance and diabetesR01DK081572 · NIDDK · VANDERBILT UNIVERSITY · PI CLISH, CLARY B, GERSZTEN, ROBERT E · 2008 to 2025
$9.3M
CONTROL OF ADIPOCYTE GENE EXPRESSION AND PHYSIOLOGYR37DK031405 · NIDDK · DANA-FARBER CANCER INSTITUTE · PI SPIEGELMAN, BRUCE M. · 1996 to 2013
$8.2M
HERITAGE STUDY: GENETICS, EXERCISE &RISK FACTORSR01HL045670 · NHLBI · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI RANKINEN, TUOMO · 1992 to 2010
$6.8M
Metabolomic Biomarkers of Early Myocardial InjuryR01HL098280 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI GERSZTEN, ROBERT E, SABATINE, MARC S · 2010 to 2014
$3.7M
CONTROL OF LIPOGENIC ENZYME SYNTHESIS IN ADIPOCYTESR01DK031405 · NIDDK · DANA-FARBER CANCER INSTITUTE · PI SPIEGELMAN, BRUCE M. · 1986 to 2018
$2.9M
Human Cell-Based Models of Primary Adipocyte DisordersR01DK095384 · NIDDK · HARVARD UNIVERSITY · PI COWAN, CHAD ALBERT · 2012 to 2016
$1.8M
THE FRAMINGHAM HEART STUDY-N01HC25195-268025195-268025195N01HC025195 · HC · TRUSTEES OF BOSTON UNIVERSITY · PI WOLF, PHILIP A · 2002 to 2006
–
NHLBI NIH HHS N01 HC025195NHLBI NIH HHS N01-HC-25195NHLBI NIH HHS R01 HL045670NHLBI NIH HHS R01-HL045670NHLBI NIH HHS R01 HL098280NIDDK NIH HHS DK 31405NIDDK NIH HHS R01 DK031405NIDDK NIH HHS R01 DK081572NIDDK NIH HHS R01 DK095384NIDDK NIH HHS R37 DK031405
6 · The paper itself

Abstract

The transcriptional coactivator peroxisome proliferator-activated receptor-gamma coactivator-1α (PGC-1α) regulates metabolic genes in skeletal muscle and contributes to the response of muscle to exercise. Muscle PGC-1α transgenic expression and exercise both increase the expression of thermogenic genes within white adipose. How the PGC-1α-mediated response to exercise in muscle conveys signals to other tissues remains incompletely defined. We employed a metabolomic approach to examine metabolites secreted from myocytes with forced expression of PGC-1α, and identified β-aminoisobutyric acid (BAIBA) as a small molecule myokine. BAIBA increases the expression of brown adipocyte-specific genes in white adipocytes and β-oxidation in hepatocytes both in vitro and in vivo through a PPARα-mediated mechanism, induces a brown adipose-like phenotype in human pluripotent stem cells, and improves glucose homeostasis in mice. In humans, plasma BAIBA concentrations are increased with exercise and inversely associated with metabolic risk factors. BAIBA may thus contribute to exercise-induced protection from metabolic diseases.

Indexed as

Adipocytes, BrownAdipocytes, WhiteAdipose Tissue, BrownAdipose Tissue, WhiteAminoisobutyric AcidsAnimalsCardiovascular DiseasesCell DifferentiationExerciseGene Expression RegulationGlucose Tolerance TestHumansInduced Pluripotent Stem CellsLiverMetabolic DiseasesMice3-aminoisobutyric acidAminoisobutyric AcidsPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPPAR alphaPpargc1a protein, mouseTranscription Factors

Identifiers

PMID24411942
PMCPMC4017355
OpenAlexW1974559463

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.