Trial reportJournal of studies on alcohol and drugs2014
Subjective responses to alcohol in the lab predict neural responses to alcohol cues.
Trial report in Journal of studies on alcohol and drugs, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 23 citations in OpenAlex.
- Neuroimaging findings from an experimental pharmacology trial of naltrexone in heavy drinkers of East Asian descent.Drug and alcohol dependence · 2019Trial
- The Effects of Pharmacological Opioid Blockade on Neural Measures of Drug Cue-Reactivity in Humans.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Trial
- FGF21 analogue PF-05231023 on alcohol consumption and neuronal activity in the nucleus accumbens.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- The Effects of Alcohol in Groups of Heavy Drinking Young Adults: A Multi-Modal Investigation of Alcohol Responses in a Laboratory Social Setting.Clinical psychological science : a journal of the Association for Psychological Science · 2025Article
- Development and Validation of the Positive Outcomes of Cannabis Use Scale (POCUS) Among Predominantly White Adults in the United States.Assessment · 2025Article
- Moderators of subjective response to alcohol in the human laboratory.Alcoholism, clinical and experimental research · 2022Article
- Effect of alcohol, tobacco, and cannabis co-use on gray matter volume in heavy drinkers.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2021Article
- Drug-Induced Craving for Methamphetamine Is Associated With Neural Methamphetamine Cue Reactivity.Journal of studies on alcohol and drugs · 2019Article
- Development, Initial Testing and Challenges of an Ecologically Valid Reward Prediction Error FMRI Task for Alcoholism.Alcohol and alcoholism (Oxford, Oxfordshire) · 2017Article
- Smells like inhibition: The effects of olfactory and visual alcohol cues on inhibitory control.Psychopharmacology · 2016Article
- Investigating dimensionality and measurement bias of DSM-5 alcohol use disorder in a representative sample of the largest metropolitan area in South America.Drug and alcohol dependence · 2015Article
- The association between cue-reactivity in the precuneus and level of dependence on nicotine and alcohol.Drug and alcohol dependence · 2014Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
objectiveSubjective responses to alcohol represent a biologically based, genetically moderated, and clinically informative marker of alcoholism risk; however, the physiology underlying this phenotype remains unclear. This study tested whether subjective responses during alcohol administration predict neural responses to alcohol cues in the scanner and whether these neural responses differ between OPRM1 genotypes.
methodTwenty alcohol-dependent individuals were recruited (10 G-allele carriers; 6 women; Mage = 29.4) for a within-subjects alcohol administration in the laboratory and a functional magnetic resonance imaging session consisting of an alcohol taste cues task. Laboratory assessments of alcohol high, liking, craving, and positive and negative reinforcement during alcohol administration were entered as predictors of neural response to the presentation of alcohol cues versus water cues in the scanner and further tested for OPRM1 genotype moderation (whole-brain cluster-corrected at Z > 1.96, p < .05).
resultsAlcohol craving during alcohol administration predicted less neural activity, whereas alcohol reinforcement predicted greater neural activity to alcohol cues versus water cues in regions including the precuneus, posterior cingulate gyrus, and lingual gyrus. Alcohol high predicted greater neural activity to alcohol cues in regions including the precuneus and anterior cingulate cortex. OPRM1 genotype was found to moderate these relationships. No results were observed for alcohol liking.
conclusionsThis study provides initial evidence that subjective responses to alcohol, namely craving, high, and the reinforcing properties of alcohol, predict neural markers of alcohol cue reactivity. These results support the validity of laboratory and neuroimaging measures of subjective responses to alcohol and offer an integration of these methods in a sample of alcohol-dependent individuals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.