ArticleJournal of the American Association for Laboratory Animal Science : JAALAS2014
Effects of housing condition and cage change on characteristics of sleep in mice.
Article in Journal of the American Association for Laboratory Animal Science : JAALAS, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- A systematic review of the development and application of home cage monitoring in laboratory mice and rats.BMC biology · 2023Pooled it
- Social rank and social environment combinedly affect REM sleep in mice.Scientific reports · 2026Article
- Effects of Cage Change and Nest Transfer on Artificial Intelligence-Measured Behaviors in Male C57BL/6 Mice.Journal of the American Association for Laboratory Animal Science : JAALAS · 2026Article
- Using Machine Learning and Predictive Artificial Intelligence to Determine Cage Change Frequency for Mice Housed in Individually Ventilated Cages and Drive Vivarium Operational Efficiency.Journal of the American Association for Laboratory Animal Science : JAALAS · 2025Article
- At the Intersection of Pain and Sleep: a Roadmap for Preclinical Pain Research.Frontiers in pain research (Lausanne, Switzerland) · 2025Review
- Neurophysiological and behavioral synchronization in group-living and sleeping mice.Current biology : CB · 2024Article
- Accurate locomotor activity profiles of group-housed mice derived from home cage monitoring data.Frontiers in neuroscience · 2024Article
- Data repurposing from digital home cage monitoring enlightens new perspectives on mouse motor behaviour and reduction principle.Scientific reports · 2023Article
- Rapid ammonia build-up in small individually ventilated mouse cages cannot be overcome by adjusting the amount of bedding.Lab animal · 2023Article
- Histological analysis of sleep and circadian brain circuitry in cranial radiation-induced hypersomnolence (C-RIH) mouse model.Scientific reports · 2022Article
- Scalable and modular wireless-network infrastructure for large-scale behavioural neuroscience.Nature biomedical engineering · 2022Article
- Influence of Pair-housing on Sleep Parameters Evaluated with Actigraphy in Female Rhesus Monkeys.Journal of the American Association for Laboratory Animal Science : JAALAS · 2022Article
- Article
- Using Home-Cage Monitoring to Determine the Impact of Timed Mating on Male Mouse Welfare.Frontiers in neuroscience · 2022Article
- Effects of Laboratory Housing Conditions on Core Temperature and Locomotor Activity in Mice.Journal of the American Association for Laboratory Animal Science : JAALAS · 2021Article
- Dietary Options for Rodents in the Study of Obesity.Nutrients · 2020Review
- Noninvasive three-state sleep-wake staging in mice using electric field sensors.Journal of neuroscience methods · 2020Article
- Automated and Continuous Monitoring of Animal Welfare through Digital Alerting.Comparative medicine · 2020Article
- Review
- Interacting Influences of Sleep, Pain, and Analgesic Medications on Sleep Studies in Rodents.Comparative medicine · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Although human subjects are widely used to study sleep and sleep disorders, animals have been invaluable in developing our understanding of the physiology of sleep and underlying mechanisms of sleep disorders. Environmental stimuli are likely to modify sleep in both animals and people, suggesting that environmental stability must be controlled carefully by both husbandry and research staff to allow collection of valid results with minimal numbers of animals. However, few studies have measured the effects of cage condition on sleep parameters in mice. Current guidelines recommend social housing and environmental enrichment for standard rodent housing. Environmental factors such as these create potential confounds in studies for which facets of sleep are outcome measures. We therefore sought to determine whether cage changes, group housing, or single housing with a shelter altered measures of sleep in C57BL/6J mice. The resulting data indicate that 1) cage changing disrupts sleep for approximately 3 h; 2) group housing is associated with shorter bouts of rapid-eye-movement sleep (REMS) and less slow-wave sleep (SWS) during the light phase and with more REMS during the dark phase; and 3) mice housed with a shelter spend less time awake and more time in SWS, with longer bouts of SWS during the dark phase. In additional, both group housing and housing with a shelter were associated with less locomotor activity than occurred in individually housed mice without a shelter. These findings provide evidence for long-held beliefs that housing conditions must be controlled carefully in studies that require assessment of sleep.
Indexed as
Identifiers
24411777PMC3894645W51314204What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.