ArticleProstaglandins, leukotrienes, and essential fatty acids
Effect of sex hormones on n-3 polyunsaturated fatty acid biosynthesis in HepG2 cells and in human primary hepatocytes.
Article in Prostaglandins, leukotrienes, and essential fatty acids. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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Who cites it
24 citing papers in PubMed, 52 citations in OpenAlex.
- Maternal Pre-Pregnancy Obesity Attenuates Response to Omega-3 Fatty Acids Supplementation During Pregnancy.Nutrients · 2018Trial
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- Characterization of sexual dimorphism in ANGPTL4 levels and function.Journal of lipid research · 2024Article
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- Glioblastoma Multiforme Tumors in Women Have a Lower Expression of Fatty Acid ElongasesBrain sciences · 2022Article
- Genistein Regulates Lipid Metabolism via Estrogen Receptor β and Its Downstream Signal Akt/mTOR in HepG2 Cells.Nutrients · 2021Article
- Article
- Expression ofBiomolecules · 2020Article
- Gender Difference on the Effect of Omega-3 Polyunsaturated Fatty Acids on Acetaminophen-Induced Acute Liver Failure.Oxidative medicine and cellular longevity · 2020Article
- Fatty acid desaturase 2 is up-regulated by the treatment with statin through geranylgeranyl pyrophosphate-dependent Rho kinase pathway in HepG2 cells.Scientific reports · 2019Article
- Article
- Polyunsaturated Fatty Acid Biosynthesis Involving Δ8 Desaturation and Differential DNA Methylation ofFrontiers in immunology · 2018Article
- Resveratrol Modulates Desaturase Expression and Fatty Acid Composition of Cultured Hepatocytes.Frontiers in nutrition · 2018Article
- Atorvastatin increases Fads1, Fads2 and Elovl5 gene expression via the geranylgeranyl pyrophosphate-dependent Rho kinase pathway in 3T3-L1 cells.Molecular medicine reports · 2017Article
- Rye polyphenols and the metabolism of n-3 fatty acids in rats: a dose dependent fatty fish-like effect.Scientific reports · 2017Article
- Long-chainJournal of nutritional science · 2017Review
- Association of maternal weight with FADS and ELOVL genetic variants and fatty acid levels- The PREOBE follow-up.PloS one · 2017Article
- Differences in long chain polyunsaturates composition and metabolism in male and female rats.Prostaglandins, leukotrienes, and essential fatty acids · 2016Article
- Effects of Sex, Drinking History, and Omega-3 and Omega-6 Fatty Acids Dysregulation on the Onset of Liver Injury in Very Heavy Drinking Alcohol-Dependent Patients.Alcoholism, clinical and experimental research · 2016Article
- Folic acid induces cell type-specific changes in the transcriptome of breast cancer cell lines: a proof-of-concept study.Journal of nutritional science · 2016Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Female humans and rodents have been shown to have higher 22:6n-3 status and synthesis than males. It is unclear which sex hormone is involved. We investigated the specificity of the effects of physiological concentrations of sex hormones in vitro on the mRNA expression of genes involved in polyunsaturated fatty acid (PUFA) biosynthesis and on the conversion of [d5]-18:3n-3 to longer chain fatty acids. Progesterone, but not 17α-ethynylestradiol or testosterone, increased FADS2, FADS1, ELOVl 5 and ELOVl 2 mRNA expression in HepG2 cells, but only FADS2 in primary human hepatocytes. In HepG2 cells, these changes were accompanied by hypomethylation of specific CpG loci in the FADS2 promoter. Progesterone, not 17α-ethynylestradiol or testosterone, increased conversion of [d5]-18:3n-3 to 20:5n-3, 22:5n-3 and 22:6n-3. These findings show that progesterone increases n-3 PUFA biosynthesis by up-regulating the mRNA expression of genes involved in this pathway, possibly via changes in the epigenetic regulation of FADS2.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.