Evidence map›Paper›PMID 24411643›Full record

ArticleLancet (London, England)2014

Biomedical research: increasing value, reducing waste.

Malcolm R Macleod, Susan Michie, Ian Roberts, Ulrich Dirnagl, Iain Chalmers, John P A Ioannidis, Rustam Al-Shahi Salman, An-Wen Chan, Paul Glasziou

Abstract read
PubMed Publisher
In one paragraph

Article in Lancet (London, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 402 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
402citing papers in PubMed, 11 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

402 citing papers in PubMed, 11 syntheses or guidelines pooled it.

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  20. Why reporting requires more than findings.Experimental physiology · 2026
    Article

342 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Malcolm R MacleodDivision of Clinical Neurosciences, Centre for Clinical Brain Sciences, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK; Department of Neurology, NHS Forth Valley, Larbert, UK. Electronic address: malcolm.macleod@ed.ac.uk.
Susan MichieDivision of Psychology and Language Sciences, University College London, London, UK.
Ian RobertsDepartment of Population Health, London School of Hygiene and Tropical Medicine, London, UK.
Ulrich DirnaglCenter for Stroke Research, Charité Universitätsmedizin Berlin, Berlin, Germany.
Iain ChalmersJames Lind Initiative, Oxford, UK.
John P A IoannidisStanford Prevention Research Center, Department of Medicine, School of Medicine, Stanford University, Stanford, CA, USA; Division of Epidemiology, Department of Health Research and Policy, School of Medicine, Stanford University, Stanford, CA, USA; Department of Statistics, School of Humanities and Sciences, Stanford University, Stanford, CA, USA; Meta-Research Innovation Center at Stanford (METRICS), Stanford University, Stanford, CA, USA.
Rustam Al-Shahi SalmanDivision of Clinical Neurosciences, Centre for Clinical Brain Sciences, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK.
An-Wen ChanWomen's College Research Institute, Department of Medicine, Women's College Hospital, University of Toronto, Toronto, ON, Canada.
Paul GlasziouCentre for Research in Evidence-Based Practice, Bond University, Robina, Gold Coast, QLD, Australia.

Funding

Department of Health NF-SI-0611-10057Medical Research Council G1002605National Centre for the Replacement, Refinement and Reduction of Animals in Research NC/L000970/1
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Biomedical ResearchEfficiencyPeer ReviewResearch Support as Topic

Identifiers

PMID24411643

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.