Evidence map›Paper›PMID 24411483›Full record

ArticleNeurobiology of aging2014

Apolipoprotein E epsilon 4 allele is associated with ventricular expansion rate and surface morphology in dementia and normal aging.

Florence F Roussotte, Boris A Gutman, Sarah K Madsen, John B Colby, Katherine L Narr, Paul M Thompson, Alzheimer's Disease Neuroimaging Initiative (ADNI)

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of aging, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Bibliometric Insights Into the Evolution of Atrial Fibrillation and Dementia Research 2002-2022.Medical science monitor : international medical journal of experimental and clinical research · 2024
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  15. Review
  16. Combined effects of Alzheimer risk variants in the CLU and ApoE genes on ventricular expansion patterns in the elderly.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Florence F RoussotteDepartment of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Boris A GutmanDepartment of Psychiatry, Semel Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA; Imaging Genetics Center, USC Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Sarah K MadsenDepartment of Psychiatry, Semel Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA; Imaging Genetics Center, USC Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
John B ColbyDepartment of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Katherine L NarrDepartment of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Paul M ThompsonDepartment of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA; Department of Psychiatry, Semel Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA; Imaging Genetics Center, USC Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Department of Neurology, USC Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Department of Psychiatry, USC Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Department of Radiology, USC Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Department of Engineering, USC Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Department of Pediatrics, USC Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Department of Ophthalmology, USC Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. Electronic address: pthomp@usc.edu.
Alzheimer's Disease Neuroimaging Initiative (ADNI)
University of California, Los Angeles · USUniversity of Southern California · US

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)U24AG021886 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI TATIANA M. FOROUD · 2002 to 2026
$119.8M
RECRUITMENT COREU19AG010483 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FELDMAN, HOWARD · 2013 to 2020
$80.6M
UC Davis Alzheimer's Disease Core CenterP30AG010129 · NIA · UNIVERSITY OF CALIFORNIA DAVIS · PI DECARLI, CHARLES · 1991 to 2020
$28.3M
TR&D3: Intrinsic Surface MappingP41EB015922 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI VAN HORN, JOHN DARRELL · 2012 to 2022
$14.1M
Alzheimer's disease risk analyzed using population imaging genomicsR01AG040060 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2011 to 2016
$2.5M
Empowering Personalized Medicine: Integrating Imaging, Genetics, and BiomarkersR01MH097268 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI COPPOLA, GIOVANNI, THOMPSON, PAUL M · 2012 to 2014
$1.3M
"MR Morphometrics and Cognitive Decline Rate in Large-Scale Aging Studies"K01AG030514 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CARMICHAEL, OWEN T. · 2008 to 2012
$495k
NIA NIH HHS K01 AG030514NIA NIH HHS P30 AG010129NIA NIH HHS R01 AG040060NIA NIH HHS U01 AG024904NIA NIH HHS U19 AG010483NIA NIH HHS U24 AG021886NIBIB NIH HHS P41 EB015922NIMH NIH HHS R01 MH097268
6 · The paper itself

Abstract

The apolipoprotein E epsilon 4 allele (ApoE-ε4) is the strongest known genetic risk factor for late onset Alzheimer's disease. Expansion of the lateral ventricles occurs with normal aging, but dementia accelerates this process. Brain structure and function depend on ApoE genotype not just for Alzheimer's disease patients but also in healthy elderly individuals, and even in asymptomatic young individuals. Therefore, we hypothesized that the ApoE-ε4 allele is associated with altered patterns of longitudinal ventricular expansion, in dementia and normal aging. We tested this hypothesis in a large sample of elderly participants, using a linear discriminant analysis-based approach. Carrying more ApoE-ε4 alleles was associated with faster ventricular expansion bilaterally and with regional patterns of lateral ventricle morphology at 1- and 2-year follow up, after controlling for sex, age, and dementia status. ApoE genotyping is considered critical in clinical trials of Alzheimer's disease. These findings, combined with earlier investigations showing that ApoE is also directly implicated in other conditions, suggest that the selective enrollment of ApoE-ε4 carriers may empower clinical trials of other neurological disorders.

Indexed as

AllelesAgedAged, 80 and overAgingAlzheimer DiseaseApolipoprotein E4Cerebral VentriclesCognitive DysfunctionDatabases, FactualDementiaFemaleFollow-Up StudiesGenotypeHeterozygoteHumansMagnetic Resonance ImagingApolipoprotein E4ApoEDementiaNeuroimaging geneticsStructural MRIVentricular expansion

Identifiers

PMID24411483
PMCPMC3961511
OpenAlexW2093642395

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.