Evidence map›Paper›PMID 24411265›Full record

ArticleBiophysical journal2014

Quantification of magnetically induced changes in ECM local apparent stiffness.

Sahan C B Herath, Du Yue, Shi Hui, Min-Cheol Kim, Dong-An Wang, Qingguo Wang, Krystyn J Van Vliet, Harry Asada, Peter C Y Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biophysical journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. The extracellular matrix in development.Development (Cambridge, England) · 2020
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sahan C B HerathDepartment of Mechanical Engineering, National University of Singapore, Singapore; Biosystem and Micromechanics Interdisciplinary Research Group, Singapore-MIT Alliance for Research and Technology Program, Singapore.
Du YueDepartment of Mechanical Engineering, National University of Singapore, Singapore; Biosystem and Micromechanics Interdisciplinary Research Group, Singapore-MIT Alliance for Research and Technology Program, Singapore.
Shi HuiBiosystem and Micromechanics Interdisciplinary Research Group, Singapore-MIT Alliance for Research and Technology Program, Singapore.
Min-Cheol KimBiosystem and Micromechanics Interdisciplinary Research Group, Singapore-MIT Alliance for Research and Technology Program, Singapore.
Dong-An WangDivision of Bioengineering Nanyang Technological University, Singapore.
Qingguo WangDepartment of Electrical and Computer Engineering, National University of Singapore, Singapore.
Krystyn J Van VlietBiosystem and Micromechanics Interdisciplinary Research Group, Singapore-MIT Alliance for Research and Technology Program, Singapore; Department of Materials Science & Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts.
Harry AsadaBiosystem and Micromechanics Interdisciplinary Research Group, Singapore-MIT Alliance for Research and Technology Program, Singapore; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts.
Peter C Y ChenDepartment of Mechanical Engineering, National University of Singapore, Singapore; Biosystem and Micromechanics Interdisciplinary Research Group, Singapore-MIT Alliance for Research and Technology Program, Singapore. Electronic address: mpechenp@nus.edu.sg.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The stiffness of the extracellular matrix (ECM) is known to influence cell behavior. The ability to manipulate the stiffness of ECM has important implications in understanding how cells interact mechanically with their microenvironment. This article describes an approach to manipulating the stiffness ECM, whereby magnetic beads are embedded in the ECM through bioconjugation between the streptavidin-coated beads and the collagen fibers and then manipulated by an external magnetic field. It also reports both analytical results (obtained by formal modeling and numerical simulation) and statistically meaningful experimental results (obtained by atomic force microscopy) that demonstrate the effectiveness of this approach. These results clearly suggest the possibility of creating desired stiffness gradients in ECM in vitro to influence cell behavior.

Indexed as

Elastic ModulusMagnetic FieldsAnimalsCollagenExtracellular MatrixMicroscopy, Atomic ForceMicrospheresModels, BiologicalRatsStreptavidinCollagenStreptavidin

Identifiers

PMID24411265
PMCPMC3907242

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.