ArticleBiophysical journal2014
Physical damage on giant vesicles membrane as a result of methylene blue photoirradiation.
Article in Biophysical journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 79 citations in OpenAlex.
- Photoswitchable Molecular Motor Phospholipid: Synthesis, Characterization, and Integration into Lipid Vesicles.Langmuir : the ACS journal of surfaces and colloids · 2025Article
- Iron-Induced Lipid Oxidation Alters Membrane Mechanics Favoring Permeabilization.Langmuir : the ACS journal of surfaces and colloids · 2024Article
- Curvature-Assisted Vesicle Explosion Under Light-Induced Asymmetric Oxidation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Stimuli-Responsive Liposomes of 5-Fluorouracil: Progressive Steps for Safe and Effective Treatment of Colorectal Cancer.Pharmaceutics · 2024Review
- New Insights in Phenothiazinium-Mediated Photodynamic Inactivation of Candida Auris.Journal of fungi (Basel, Switzerland) · 2023Article
- Directly imaging emergence of phase separation in peroxidized lipid membranes.Communications chemistry · 2023Article
- Assessing membrane material properties from the response of giant unilamellar vesicles to electric fields.Advances in physics: X · 2023Article
- Use of giant unilamellar lipid vesicles as antioxidant carriers in in vitro culture medium of bovine embryos.Scientific reports · 2022Article
- Antioxidant Properties of Ergosterol and Its Role in Yeast Resistance to Oxidation.Antioxidants (Basel, Switzerland) · 2021Article
- Effects of antimicrobial photodynamic therapy on antibiotic-resistant Escherichia coli.Photodiagnosis and photodynamic therapy · 2020Article
- Review
- Lipid Unsaturation Properties Govern the Sensitivity of Membranes to Photoinduced Oxidative Stress.Biophysical journal · 2019Article
- Frontiers of Complex Disease Mechanisms: Membrane Surface Tension May Link Genotype to Phenotype in Glaucoma.Frontiers in cell and developmental biology · 2018Article
- Enhanced efficiency of cell death by lysosome-specific photodamage.Scientific reports · 2017Article
- A Molecular Rotor that Measures Dynamic Changes of Lipid Bilayer Viscosity Caused by Oxidative Stress.Chemistry (Weinheim an der Bergstrasse, Germany) · 2016Article
- Proteoliposomes with the ability to transport Ca(2+) into the vesicles and hydrolyze phosphosubstrates on their surface.Archives of biochemistry and biophysics · 2015Article
- Low levels of lipid oxidation radically increase the passive permeability of lipid bilayers.Soft matter · 2015Article
- Membrane changes under oxidative stress: the impact of oxidized lipids.Biophysical reviews · 2014Review
- Developing giant plasma membrane vesicles from Leishmania cells to investigate the role of membrane proteins in photodynamic inactivation.Photochemistry and photobiologyArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study we pursue a closer analysis of the photodamage promoted on giant unilamellar vesicles membranes made of dioleoyl-sn-glycero-3-phosphocholine (DOPC) or 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC), by irradiating methylene blue present in the giant unilamellar vesicles solution. By means of optical microscopy and electro-deformation experiments, the physical damage on the vesicle membrane was followed and the phospholipids oxidation was evaluated in terms of changes in the membrane surface area and permeability. As expected, oxidation modifies structural characteristics of the phospholipids that lead to remarkable membrane alterations. By comparing DOPC- with POPC-made membranes, we observed that the rate of pore formation and vesicle degradation as a function of methylene blue concentration follows a diffusion law in the case of DOPC and a linear variation in the case of POPC. We attributed this scenario to the nucleation process of oxidized species following a diffusion-limited growth regime for DOPC and in the case of POPC a homogeneous nucleation process. On the basis of these premises, we constructed models based on reaction-diffusion equations that fit well with the experimental data. This information shows that the outcome of the photosensitization reactions is critically dependent on the type of lipid present in the membrane.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.