ArticleBiophysical journal2014
Theoretical analysis of membrane tension in moving cells.
Article in Biophysical journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Membrane bending energy selects for compact growth of protein assemblies.bioRxiv : the preprint server for biology · 2025Article
- Intracellular pressure controls the propagation of tension in crumpled cell membranes.Nature communications · 2025Article
- Human Immunodeficiency Virus Type 1 Gag Polyprotein Modulates Membrane Physical Properties like a Surfactant: Potential Implications for Virus Assembly.ACS infectious diseases · 2024Article
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- Article
- Spatial organization of lysosomal exocytosis relies on membrane tension gradients.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Plant cell polarity as the nexus of tissue mechanics and morphogenesis.Nature plants · 2021Review
- Microtubule-independent movement of the fission yeast nucleus.Journal of cell science · 2021Article
- On the adhesion-velocity relation and length adaptation of motile cells on stepped fibronectin lanes.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Stick-slip model for actin-driven cell protrusions, cell polarization, and crawling.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Cell Membranes Resist Flow.Cell · 2018Article
- Membrane tension controls adhesion positioning at the leading edge of cells.The Journal of cell biology · 2017Article
- Epsin N-terminal Homology Domain (ENTH) Activity as a Function of Membrane Tension.The Journal of biological chemistry · 2016Article
- Membrane tension and membrane fusion.Current opinion in structural biology · 2015Review
- Regulation of membrane-shape transitions induced by I-BAR domains.Biophysical journal · 2015Article
- Front-to-rear membrane tension gradient in rapidly moving cells.Biophysical journal · 2015Article
- Myoblast fusion: playing hard to get.Developmental cell · 2015Article
- Membrane tension and peripheral protein density mediate membrane shape transitions.Nature communications · 2015Article
- Mechanisms shaping cell membranes.Current opinion in cell biology · 2014Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lateral tension in cell plasma membranes plays an essential role in regulation of a number of membrane-related intracellular processes and cell motion. Understanding the physical factors generating the lateral tension and quantitative determination of the tension distribution along the cell membrane is an emerging topic of cell biophysics. Although experimental data are accumulating on membrane tension values in several cell types, the tension distribution along the membranes of moving cells remains largely unexplored. Here we suggest and analyze a theoretical model predicting the tension distribution along the membrane of a cell crawling on a flat substrate. We consider the tension to be generated by the force of actin network polymerization against the membrane at the cell leading edge. The three major factors determining the tension distribution are the membrane interaction with anchors connecting the actin network to the lipid bilayer, the membrane interaction with cell adhesions, and the force developing at the rear boundary due to the detachment of the remaining cell adhesion from the substrate in the course of cell crawling. Our model recovers the experimentally measured values of the tension in fish keratocytes and their dependence on the number of adhesions. The model predicts, quantitatively, the tension distribution between the leading and rear membrane edges as a function of the area fractions of the anchors and the adhesions.
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