ArticleBiophysical journal2014
Border forces and friction control epithelial closure dynamics.
Article in Biophysical journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed.
- Physical models of embryonic epithelial healing.PLoS computational biology · 2026Review
- Measurement of tissue viscosity to relate force and motion in collective cell migration.Soft matter · 2026Article
- Accessible and cost-effective methods for patterning cell monolayers on compliant substrates.PloS one · 2026Article
- Frictiotaxis underlies focal adhesion-independent durotaxis.Nature communications · 2025Article
- Initiation of epithelial wound closure by an active instability at the purse string.Biophysical journal · 2025Article
- Computational modeling and simulation of epithelial wound closure.Scientific reports · 2023Article
- Contractility-induced self-organization of smooth muscle cells: from multilayer cell sheets to dynamic three-dimensional clusters.Communications biology · 2023Article
- Homeotic compartment curvature and tension control spatiotemporal folding dynamics.Nature communications · 2023Article
- Self-assembly of tessellated tissue sheets by expansion and collision.Nature communications · 2022Article
- Actin Stress Fibers Response and Adaptation under Stretch.International journal of molecular sciences · 2022Article
- Effect of substrate stiffness on friction in collective cell migration.Scientific reports · 2022Article
- Collective durotaxis of cohesive cell clusters on a stiffness gradient.The European physical journal. E, Soft matter · 2022Article
- Tissue Engineering with Mechanically Induced Solid-Fluid Transitions.Advanced materials (Deerfield Beach, Fla.) · 2022Article
- Collective migration during a gap closure in a two-dimensional haptotactic model.Scientific reports · 2021Article
- Adhesion-mediated heterogeneous actin organization governs apoptotic cell extrusion.Nature communications · 2021Article
- Reversible elastic phase field approach and application to cell monolayers.The European physical journal. E, Soft matter · 2020Article
- Dynamic instability and migration modes of collective cells in channels.Journal of the Royal Society, Interface · 2019Article
- Tissue Fluidity Promotes Epithelial Wound Healing.Nature physics · 2019Article
- Dynamic and static analyses of glass-like properties of three-dimensional tissues.Biophysics and physicobiology · 2019Article
- Wound Healing Coordinates Actin Architectures to Regulate Mechanical Work.Nature physics · 2019Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We study the closure dynamics of a large number of well-controlled circular apertures within an epithelial monolayer, where the collective cell migration responsible for epithelization is triggered by the removal of a spatial constraint rather than by scratching. Based on experimental observations, we propose a physical model that takes into account border forces, friction with the substrate, and tissue rheology. Border protrusive activity drives epithelization despite the presence of a contractile actomyosin cable at the periphery of the wound. The closure dynamics is quantified by an epithelization coefficient, defined as the ratio of protrusive stress to tissue-substrate friction, that allows classification of different phenotypes. The same analysis demonstrates a distinct signature for human cells bearing the oncogenic RasV12 mutation, demonstrating the potential of the approach to quantitatively characterize metastatic transformations.
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Registered trials
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