Evidence map›Paper›PMID 24411074›Full record

SynthesisPsychiatry research2014

Revisiting the therapeutic effect of rTMS on negative symptoms in schizophrenia: a meta-analysis.

Chuan Shi, Xin Yu, Eric F C Cheung, David H K Shum, Raymond C K Chan

Open access · greenAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Psychiatry research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 2 pooled it
9.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 2 syntheses or guidelines pooled it, 142 citations in OpenAlex.

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  12. Tumor suppressive effect of low-frequency repetitive transcranial magnetic stimulation on glioblastoma progression.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 2 countries.

Chuan ShiNeuropsychology and Applied Cognitive Neuroscience Laboratory, Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, China; Institute of Mental Health, Peking University, Beijing, China; Key Laboratory of Mental Health, Ministry of Health, Peking University, Beijing, China.
Xin YuInstitute of Mental Health, Peking University, Beijing, China; Key Laboratory of Mental Health, Ministry of Health, Peking University, Beijing, China.
Eric F C CheungCastle Peak Hospital, Hong Kong Special Administrative Region, China.
David H K ShumBehavioural Basis of Health Research Program, Griffith Health Institute, Griffith University, Gold Coast, Australia.
Raymond C K ChanNeuropsychology and Applied Cognitive Neuroscience Laboratory, Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, China. Electronic address: rckchan@psych.ac.cn.
Castle Peak Hospital · CNGriffith University · AUInstitute of Psychology, Chinese Academy of Sciences · CNPeking University · CNPeking University Sixth Hospital · CN

Funding

Training Program in International Mental HealthD43TW005809 · FIC · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI GOOD, BYRON J. · 2001 to 2010
$2.3M
FIC NIH HHS D43 TW005809FIC NIH HHS D43TW5809
6 · The paper itself

Abstract

This study sought to determine the moderators in the treatment effect of repetitive transcranial magnetic stimulation (rTMS) on negative symptoms in schizophrenia. We performed a meta-analysis of prospective studies on the therapeutic application of rTMS in schizophrenia assessing the effects of both low-frequency and high-frequency rTMS on negative symptoms. Results indicate that rTMS is effective in alleviating negative symptoms in schizophrenia. The effect size was moderate (0.63 and 0.53, respectively). The effect size of rTMS on negative symptoms in sham-controlled trials was 0.80 as measured by the SANS and 0.41 as measured by the PANSS. A longer duration of illness was associated with poorer efficacy of rTMS on negative symptoms. A 10 Hz setting, at least 3 consecutive weeks of treatment, treatment site at the left dorsolateral prefrontal cortex (DLPFC) and a 110% motor threshold (MT) were found to be the best rTMS parameters for the treatment of negative symptoms. The results of our meta-analysis suggest that rTMS is an effective treatment option for negative symptoms in schizophrenia. The moderators of rTMS on negative symptoms included duration of illness, stimulus frequency, duration of illness, position and intensity of treatment as well as the type of outcome measures used.

Indexed as

Schizophrenic PsychologyAdultHumansMaleNegativismPrefrontal CortexProspective StudiesSchizophreniaTranscranial Magnetic StimulationTreatment OutcomeInterventionMeta-analysisNegative symptomsRepetitive transcranial magnetic stimulationSchizophrenia

Identifiers

PMID24411074
PMCPMC4127383
OpenAlexW1980770127

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.