ArticleBMC genetics2014
Evidence for positive selection of taurine genes within a QTL region on chromosome X associated with testicular size in Australian Brahman cattle.
Article in BMC genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Genetic mechanisms underlying spermatic and testicular traits within and among cattle breeds: systematic review and prioritization of GWAS results.Journal of animal science · 2018Pooled it
- Multi-breed genomic predictions and functional variants for fertility of tropical bulls.PloS one · 2023Article
- Extensive Variation in Gene Expression is Revealed in 13 Fertility-Related Genes Using RNA-Seq, ISO-Seq, and CAGE-Seq From Brahman Cattle.Frontiers in genetics · 2022Article
- Effect of genomic X-chromosome regions on Nelore bull fertility.Journal of applied genetics · 2021Article
- Identification of genomic regions that exhibit sexual dimorphism for size and muscularity in cattle.Journal of animal science · 2021Article
- Article
- Population genomics identifies patterns of genetic diversity and selection in chicken.BMC genomics · 2019Article
- A novel TEX11 mutation induces azoospermia: a case report of infertile brothers and literature review.BMC medical genetics · 2018Review
- Androgen receptor gene polymorphism in zebra species.Meta gene · 2015Article
- TEX11 is mutated in infertile men with azoospermia and regulates genome-wide recombination rates in mouse.EMBO molecular medicine · 2015Article
- Non-synonymous mutations mapped to chromosome X associated with andrological and growth traits in beef cattle.BMC genomics · 2015Article
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrevious genome-wide association studies have identified significant regions of the X chromosome associated with reproductive traits in two Bos indicus-influenced breeds: Brahman cattle and Tropical Composites. Two QTL regions on this chromosome were identified in both breeds as strongly associated with scrotal circumference measurements, a reproductive trait previously shown to be useful for selection of young bulls. Scrotal circumference is genetically correlated with early age at puberty in both male and female offspring. These QTL were located at positions 69-77 and 81-92 Mb respectively, large areas each to which a significant number of potential candidate genes were mapped.
resultsTo further characterise these regions, a bioinformatic approach was undertaken to identify novel non-synonymous SNP within the QTL regions of interest in Brahman cattle. After SNP discovery, we used conventional molecular assay technologies to perform studies of two candidate genes in both breeds. Non-synonymous SNP mapped to Testis-expressed gene 11 (Tex11) were associated (P < 0.001) with scrotal circumference in both breeds, and associations with percentage of normal sperm cells were also observed (P < 0.05). Evidence for recent selection was found as Tex11 SNP form a haplotype segment of Bos taurus origin that is retained within Brahman and Tropical Composite cattle with greatest reproductive potential.
conclusionsAssociation of non-synonymous SNP presented here are a first step to functional genetic studies. Bovine species may serve as a model for studying the role of Tex11 in male fertility, warranting further in-depth molecular characterisation.
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