ArticleJournal of virology1987
Rabies virus infection of cultured rat sensory neurons.
Article in Journal of virology, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 94 citations in OpenAlex.
- Ex vivo study of neuroinvasive and neurotropic viruses: what is current and what is next.FEMS microbiology reviews · 2025Review
- Examining the molecular clock hypothesis for the contemporary evolution of the rabies virus.PLoS pathogens · 2024Article
- Limited evidence for anatomical contacts between intestinal GLP-1 cells and vagal neurons in male mice.Scientific reports · 2024Article
- Lyssaviruses and the Fatal Encephalitic Disease Rabies.Frontiers in immunology · 2021Review
- Article
- Overexpression of MAP2 and NF-H Associated with Dendritic Pathology in the Spinal Cord of Mice Infected with Rabies Virus.Viruses · 2018Article
- Safety and neutralizing rabies antibody in healthy subjects given a single dose of rabies immune globulin caprylate/chromatography purified.Clinical pharmacology : advances and applications · 2018Article
- Subversion of the Immune Response by Rabies Virus.Viruses · 2016Review
- Perspectives in Diagnosis and Treatment of Rabies Viral Encephalitis: Insights from Pathogenesis.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2016Review
- Anterograde glycoprotein-dependent transport of newly generated rabies virus in dorsal root ganglion neurons.Journal of virology · 2014Article
- Intravenous inoculation of a bat-associated rabies virus causes lethal encephalopathy in mice through invasion of the brain via neurosecretory hypothalamic fibers.PLoS pathogens · 2009Article
- Dual transneuronal tracing in the rat entorhinal-hippocampal circuit by intracerebral injection of recombinant rabies virus vectors.Frontiers in neuroanatomy · 2009Article
- Production of compartmented cultures of rat sympathetic neurons.Nature protocols · 2009Article
- Untangling neural networks with dual retrograde transsynaptic viral infection.Frontiers in neuroscience · 2009Article
- The rabies virus glycoprotein receptor p75NTR is not essential for rabies virus infection.Journal of virology · 2007Article
- Role of fusion protein cleavage site in the virulence of Newcastle disease virus.Microbial pathogenesis · 2004Article
- Rabies virus infection: an update.Journal of neurovirology · 2003Review
- Rabies virus is not cytolytic for rat spinal motoneurons in vitro.Journal of neurovirology · 2002Article
- Retrograde transport of transmissible mink encephalopathy within descending motor tracts.Journal of virology · 2002Article
- Differential use of the nicotinic receptor by rabies virus based upon substrate origin.Journal of neurovirology · 2002Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The axonal transport of rabies virus (challenge virus strain of fixed virus) was studied in differentiated rat embryonic dorsal root ganglion cells. In addition, we observed the attachment of rabies virus to neuronal extensions and virus production by infected neurons. A compartmentalized cell culture system was used, allowing infection and manipulation of neuronal extensions without exposing the neural soma to the virus. The cultures consisted of 60% large neuronal cells whose extensions exhibited neurofilament structures. Rabies virus demonstrated high binding affinity to unmyelinated neurites, as suggested by assays of virus adsorption and immunofluorescence studies. The rate of axoplasmic transport of virus was 12 to 24 mm/day, including the time required for internalization of the virus into neurites. The virus transport could be blocked by cytochalasin B, vinblastine, and colchicine, none of which negatively affected the production of virus in cells once the infection was established. It was concluded that, for the retrograde transfer of rabies virus by neurites from the periphery to the neuronal soma, the integrity of tubulin- and actin-containing structures is essential. The rat sensory neurons were characterized as permissive, moderately susceptible, but low producers of rabies virus. These neurons were capable of harboring rabies virus for long periods of time and able to release virus into the culture medium without showing any morphological alterations. The involvement of sensory neurons in rabies virus pathogenesis, both in viral transport and as a site for persistent viral infection, is discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.