Trial reportRadiation oncology (London, England)2014
Change in prostate volume during extreme hypo-fractionation analysed with MRI.
Trial report in Radiation oncology (London, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Hypofractionation for clinically localized prostate cancer.The Cochrane database of systematic reviews · 2019Pooled it
- Magnetic resonance-guided simultaneous multi-focal adaptive radiotherapy for prostate, pElvis & metastases (MRgSMART-PEM) in prostate cancer: a prospective phase II study.Radiation oncology (London, England) · 2026Trial
- Clinical indicators for dose re-optimization in magnetic resonance-guided online adaptive radiotherapy for prostate cancer.Physics and imaging in radiation oncology · 2026Article
- MRI-Derived Biomarkers and Radiomic Signatures for Early, Dose-Dependent Evaluation of Prostate Cancer Radiotherapy: An Exploratory Study.Journal of imaging · 2026Article
- Kinetics of prostate volume reduction under hormonal treatment: Timing and impact on external beam radiotherapy - A PRISMA-Compliant systematic review.Clinical and translational radiation oncology · 2026Review
- Urinary tract events after radical radiotherapy (RT) for prostate cancer according to pre-RT International Prostate Symptom Score.BJU international · 2026Article
- Changes in prostate volume during prostate SBRT delivered on an MR-Linac and correlation with acute toxicity.Clinical and translational radiation oncology · 2025Article
- Ultrahypofractionated radiotherapy for localised prostate cancer: The impact of daily MRI-guided adaptive radiotherapy on delivered dose.Clinical and translational radiation oncology · 2025Article
- Volume change of the prostate during moderately hypo-fractionated radiotherapy assessed by artificial intelligence.Physics and imaging in radiation oncology · 2025Article
- Practice-based training strategy for therapist-driven prostate MR-Linac adaptive radiotherapy.Technical innovations & patient support in radiation oncology · 2023Article
- Dosimetric Impact of Intrafraction Prostate Motion and Interfraction Anatomical Changes in Dose-Escalated Linac-Based SBRT.Cancers · 2023Article
- Assessment of delivered dose in prostate cancer patients treated with ultra-hypofractionated radiotherapy on 1.5-Tesla MR-Linac.Frontiers in oncology · 2023Article
- Dosimetric comparison of MR-guided adaptive IMRT versus 3DOF-VMAT for prostate stereotactic radiotherapy.Technical innovations & patient support in radiation oncology · 2022Article
- MR-guided radiotherapy for prostate cancer: state of the art and future perspectives.The British journal of radiology · 2022Review
- Case Report: MR-Guided Adaptive Radiotherapy, Some Room to Maneuver.Frontiers in oncology · 2022Article
- Evaluation of daily online contour adaptation by radiation therapists for prostate cancer treatment on an MRI-guided linear accelerator.Clinical and translational radiation oncology · 2021Article
- Problems and Promises of Introducing the Magnetic Resonance Imaging Linear Accelerator Into Routine Care: The Case of Prostate Cancer.Frontiers in oncology · 2020Article
- MR-Guided Radiotherapy for Prostate Cancer.Frontiers in oncology · 2020Review
- MR-guidance in clinical reality: current treatment challenges and future perspectives.Radiation oncology (London, England) · 2019Review
- CBCT-based Online Adaptive Radiotherapy for Prostate Cancer: Dosimetrical Aspects and Comparison to Non-Adaptive Conventional IGRT.Technology in cancer research & treatmentArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHypo-fractionated external beam radiotherapy with narrow CTV-PTV margins is increasingly applied for prostate cancer. This demands a precise target definition and knowledge on target location and extension during treatment. It is unclear how increase in fraction size affects changes in prostate volume during treatment. Our aim was to study prostate volume changes during extreme hypo-fractionation (7 × 6.1 Gy) by using sequential MRIs.
methodsTwenty patients treated with extreme hypo-fractionation were recruited from an on-going prospective randomized phase III trial. An MRI scan was done before start of treatment, at mid treatment and at the end of radiotherapy. The prostate was delineated at each MRI and the volume and maximum extension in left-right, anterior-posterior and cranial-caudal directions were measured.
resultsThere was a significant increase in mean prostate volume (14%) at mid treatment as compared to baseline. The prostate volume remained enlarged (9%) at the end of radiotherapy. Prostate swelling was most pronounced in the anterior-posterior and cranial-caudal directions.
conclusionsExtreme hypo-fractionation induced a significant prostate swelling during treatment that was still present at the time of last treatment fraction. Our results indicate that prostate swelling is an important factor to take into account when applying treatment margins during short extreme hypo-fractionation, and that tight margins should be applied with caution.
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