ArticleBiomedical optics express2013
Optical clearing in photoacoustic flow cytometry.
Article in Biomedical optics express, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- Photoacoustic imaging for cutaneous melanoma assessment: a comprehensive review.Journal of biomedical optics · 2024Pooled it
- Tartrazine-enabled optical clearing for in vivo optical resolution photoacoustic microscopy.Biomedical optics express · 2025Article
- Review
- Confocal Raman Micro-Spectroscopy for Discrimination of Glycerol Diffusivity in Ex Vivo PorcineLife (Basel, Switzerland) · 2022Article
- Optical clearing for photoacoustic lympho- and angiography beyond conventional depth limitPhotoacoustics · 2020Article
- Biomedical Applications of Tissue Clearing and Three-Dimensional Imaging in Health and Disease.iScience · 2020Review
- In vivo liquid biopsy using Cytophone platform for photoacoustic detection of circulating tumor cells in patients with melanoma.Science translational medicine · 2019Article
- Noninvasive label-free detection of circulating white and red blood clots in deep vessels with a focused photoacoustic probe.Biomedical optics express · 2018Article
- Dynamic blood flow phantom with negative and positive photoacoustic contrasts.Biomedical optics express · 2018Article
- Current status, pitfalls and future directions in the diagnosis and therapy of lymphatic malformation.Journal of biophotonics · 2018Review
- In vivo noninvasive analysis of graphene nanomaterial pharmacokinetics using photoacoustic flow cytometry.Journal of applied toxicology : JAT · 2017Article
- Preclinical photoacoustic models: application for ultrasensitive single cell malaria diagnosis in large vein and artery.Biomedical optics express · 2016Article
- Optical clearing of skin enhanced with hyaluronic acid for increased contrast of optoacoustic imaging.Journal of biomedical optics · 2016Article
- Photoacoustic Flow Cytometry for Single Sickle Cell DetectionAnalytical cellular pathology (Amsterdam) · 2016Article
- Article
- Arterial Blood, Rather Than Venous Blood, is a Better Source for Circulating Melanoma Cells.EBioMedicine · 2015Article
- In vivo cell characteristic extraction and identification by photoacoustic flow cytography.Biomedical optics express · 2015Article
- In vivo quantitation of injected circulating tumor cells from great saphenous vein based on video-rate confocal microscopy.Biomedical optics express · 2015Article
- Accessing to arteriovenous blood flow dynamics response using combined laser speckle contrast imaging and skin optical clearing.Biomedical optics express · 2015Article
- Optimal flushing agents for integrated optical and acoustic imaging systems.Journal of biomedical optics · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Clinical applications of photoacoustic (PA) flow cytometry (PAFC) for detection of circulating tumor cells in deep blood vessels are hindered by laser beam scattering, that result in loss of PAFC sensitivity and resolution. We demonstrate biocompatible and rapid optical clearing (OC) of skin to minimize light scattering and thus, increase optical resolution and sensitivity of PAFC. OC effect was achieved in 20 min by sequent skin cleaning, microdermabrasion, and glycerol application enhanced by massage and sonophoresis. Using 0.8 mm mouse skin layer over a blood vessel in vitro phantom we demonstrated 1.6-fold decrease in laser spot blurring accompanied by 1.6-fold increase in PA signal amplitude from blood background. As a result, peak rate for B16F10 melanoma cells in blood flow increased 1.7-fold. By using OC we also demonstrated the feasibility of PA contrast improvement for human hand veins.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.