ArticleBiomedical optics express2013
Hemodynamic signature of breast cancer under fractional mammographic compression using a dynamic diffuse optical tomography system.
Article in Biomedical optics express, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Evolution of tomosynthesis.Journal of medical imaging (Bellingham, Wash.) · 2025Review
- Errors Induced by Partial Pathlength Variations Due to Mammographic Compression in Dynamic Diffuse Optical Breast Imaging.Proceedings of SPIE--the International Society for Optical Engineering · 2025Article
- Monte Carlo simulation of spatial frequency domain imaging for breast tumors during compression.Journal of biomedical optics · 2024Article
- Functional hemodynamic imaging markers for the prediction of pathological outcomes in breast cancer patients treated with neoadjuvant chemotherapy.Journal of biomedical optics · 2024Article
- Self-Guided Algorithm for Fast Image Reconstruction in Photo-Magnetic Imaging: Artificial Intelligence-Assisted Approach.Bioengineering (Basel, Switzerland) · 2024Article
- Mechanical and hemodynamic responses of breast tissue under mammographic-like compression during functional dynamic optical imaging.Biomedical optics express · 2020Article
- Impact of errors in experimental parameters on reconstructed breast images using diffuse optical tomography.Biomedical optics express · 2018Article
- Value of combining dynamic contrast enhanced ultrasound and optoacoustic tomography for hypoxia imaging.Photoacoustics · 2017Article
- Multimodal breast cancer imaging using coregistered dynamic diffuse optical tomography and digital breast tomosynthesis.Journal of biomedical optics · 2017Article
- Normalization of compression-induced hemodynamics in patients responding to neoadjuvant chemotherapy monitored by dynamic tomographic optical breast imaging (DTOBI).Biomedical optics express · 2017Article
- The state of the art in breast imaging using the Twente Photoacoustic Mammoscope: results from 31 measurements on malignancies.European radiology · 2016Observational
- Effects of breast density and compression on normal breast tissue hemodynamics through breast tomosynthesis guided near-infrared spectral tomography.Journal of biomedical optics · 2016Article
- Diffuse optical measurements of head and neck tumor hemodynamics for early prediction of chemoradiation therapy outcomes.Journal of biomedical optics · 2016Article
- Broadband optical mammography instrument for depth-resolved imaging and local dynamic measurements.The Review of scientific instruments · 2016Article
- Experimental validation of a high-resolution diffuse optical imaging modality: photomagnetic imaging.Journal of biomedical optics · 2016Article
- Frequency domain near-infrared multiwavelength imager design using high-speed, direct analog-to-digital conversion.Journal of biomedical optics · 2016Article
- Estimate of tissue composition in malignant and benign breast lesions by time-domain optical mammography.Biomedical optics express · 2014Article
- Article
- Optical Breast Imaging: A Review of Physical Principles, Technologies, and Clinical Applications.Journal of breast imagingArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Near infrared dynamic diffuse optical tomography measurements of breast hemodynamics during fractional mammographic compression offer a novel contrast mechanism for detecting breast cancer and monitoring chemotherapy. Tissue viscoelastic relaxation during the compression period leads to a slow reduction in the compression force and reveals biomechanical and metabolic differences between healthy and lesion tissue. We measured both the absolute values and the temporal evolution of hemoglobin concentration during 25-35 N of compression for 22 stage II and III breast cancer patients scheduled to undergo neoadjuvant chemotherapy. 17 patients were included in the group analysis (average tumor size 3.2 cm, range: 1.3-5.7 cm). We observed a statistically significant differential decrease in total and oxy-hemoglobin, as well as in hemoglobin oxygen saturation in tumor areas vs. healthy tissue, as early as 30 seconds into the compression period. The hemodynamic contrast is likely driven by the higher tumor stiffness and different viscoelastic relaxation rate, as well as the higher tumor oxygen metabolism rate.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.