Evidence map›Paper›PMID 24409379›Full record

ArticleBiomedical optics express2013

Assessing the mechanical properties of tissue-mimicking phantoms at different depths as an approach to measure biomechanical gradient of crystalline lens.

Shang Wang, Salavat Aglyamov, Andrei Karpiouk, Jiasong Li, Stanislav Emelianov, Fabrice Manns, Kirill V Larin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical optics express, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 33 citations in OpenAlex.

  1. Phantoms for use in optical coherence elastography.Journal of biomedical optics · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Shang WangDepartment of Biomedical Engineering, University of Houston, 3605 Cullen Boulevard, Houston, Texas 77204, USA.
Salavat AglyamovDepartment of Biomedical Engineering, The University of Texas at Austin, 107 W Dean Keeton Street, Austin, Texas 78712, USA.
Andrei KarpioukDepartment of Biomedical Engineering, The University of Texas at Austin, 107 W Dean Keeton Street, Austin, Texas 78712, USA.
Jiasong LiDepartment of Biomedical Engineering, University of Houston, 3605 Cullen Boulevard, Houston, Texas 77204, USA.
Stanislav EmelianovDepartment of Biomedical Engineering, The University of Texas at Austin, 107 W Dean Keeton Street, Austin, Texas 78712, USA.
Fabrice MannsOphthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, 1638 NW 10th Avenue, Miami, Florida 33136, USA ; Biomedical Optics and Laser Laboratory, Department of Biomedical Engineering, University of Miami College of Engineering, 1251 Memorial Drive, Coral Gables, Florida 33146, USA.
Kirill V LarinDepartment of Biomedical Engineering, University of Houston, 3605 Cullen Boulevard, Houston, Texas 77204, USA ; Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77584, USA.
The University of Texas at Austin · USUniversity of Houston · USUniversity of Miami · US

Funding

Optical Coherence Elastography of the CorneaR01EY022362 · NEI · UNIVERSITY OF HOUSTON · PI Salavat R Aglyamov, Kirill V Larin · 2012 to 2026
$6.7M
Optomechanical charactristics of lens accommodationR01EY014225 · NEI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI MANNS, FABRICE · 2002 to 2019
$5.5M
NEI NIH HHS R01 EY014225NEI NIH HHS R01 EY022362
6 · The paper itself

Abstract

We demonstrate the feasibility of using the dominant frequency of the sample surface response to a mechanical stimulation as an effective indicator for sensing the depthwise distribution of elastic properties in transparent layered phantom samples simulating the cortex and nucleus of the crystalline lens. Focused ultrasound waves are used to noninvasively interrogate the sample surface. A phase-sensitive optical coherence tomography system is utilized to capture the surface dynamics over time with nanometer scale sensitivity. Spectral analysis is performed on the sample surface response to ultrasound stimulation and the dominant frequency is calculated under particular loading parameters. Pilot experiments were conducted on homogeneous and layered tissue-mimicking phantoms. Results indicate that the mechanical layers located at different depths introduce different frequencies to the sample surface response, which are correlated with the depth-dependent elasticity of the sample. The duration and the frequency of the ultrasound excitation are also investigated for their influences on this spectrum-based detection. This noninvasive method may be potentially applied for localized and rapid assessment of the depth dependence of the mechanical properties of the crystalline lens.

Indexed as

(110.4500) Optical coherence tomography(120.5050) Phase measurement(120.7280) Vibration analysis(170.0170) Medical optics and biotechnology(170.7170) Ultrasound

Identifiers

PMID24409379
PMCPMC3862146
OpenAlexW1995163821

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.