ArticleJournal of thoracic disease2013
Expression of NF-κB, CD68 and CD105 in carotid atherosclerotic plaque.
Article in Journal of thoracic disease, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Nitrate-driven maintenance of lipid homeostasis by M2 macrophages alleviates atherosclerosis via downregulation of LOX1 expression and reduction of lipid deposition.Science China. Life sciences · 2025Article
- A Review of MicroRNAs and lncRNAs in Atherosclerosis as Well as Some Major Inflammatory Conditions Affecting Atherosclerosis.Biomedicines · 2024Review
- Modulation of Macrophage Polarization by Carbon Nanodots and Elucidation of Carbon Nanodot Uptake Routes in Macrophages.Nanomaterials (Basel, Switzerland) · 2021Article
- The Mechanisms of the Development of Atherosclerosis in Prediabetes.International journal of molecular sciences · 2021Review
- Nicotine in Senescence and Atherosclerosis.Cells · 2020Review
- Anti-atherogenic effect of Humulus japonicus in apolipoprotein E-deficient mice.International journal of molecular medicine · 2016Article
- The relationship between preoperative serum cortisol level and the stability of plaque in carotid artery stenosis patients undergoing carotid endarterectomy.Journal of thoracic disease · 2016Article
- Correlation between mimecan expression and coronary artery stenosis in patients with coronary heart disease.International journal of clinical and experimental medicine · 2015Article
- Smooth muscle immaturity in the carotid arterial neointima as a prognostic marker for systemic atherogenic cardiovascular events in the Asian male.International journal of clinical and experimental pathology · 2015Article
- Characterization of Nestin, a Selective Marker for Bone Marrow Derived Mesenchymal Stem Cells.Stem cells international · 2015Review
- Higher level of heme oxygenase-1 in patients with stroke than TIA.Journal of thoracic disease · 2014Article
- A propensity score analysis on the effect of on-pump versus off-pump coronary artery bypass grafting for patients with coronary artery disease.Journal of thoracic disease · 2014Article
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Authors and funding
8 authors.
Funding
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Abstract
Atherosclerotic plaque vulnerability is associated with cerebrovascular events in patients with carotid atherosclerosis. The aim of this study was to investigate the expression of inflammatory factors in carotid artherosclerotic plaques in order to explore its clinical significance in patients with carotid stenosis. Forty three patients with carotid stenosis were divided into symptomatic group (n=24) and asymptomatic group (n=19) based on clinical manifestation. All patients were treated with selective standard carotid endarterectomy (CEA); the carotid atherosclerotic plaques were removed surgically and studied pathologically to investigate the expression of nuclear factor-kappa κ (NF-κB), CD68 and CD105. The plaques were grouped into stable and unstable plaques based on thickness of the fibrous cap and the area of lipid-rich core in the plaques. The proportion of unstable plaques were significantly higher in symptomatic group than in asymptomatic group (70.8% vs. 63.2%, P=0.026). Results of immunohistochemisty staining showed that the expression of NF-κB, CD68 and CD105 in unstable plaques was higher than stable plaques (P<0.001). The association of the higher expression of these factors with instability of carotid plaque needs to be clarified in future study.
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