Evidence map›Paper›PMID 24409342›Full record

ArticleJournal of materials chemistry. B2013

Bacteriophage Associated Silicon Particles: Design and Characterization of a Novel Theranostic Vector with Improved Payload Carrying Potential.

Srimeenakshi Srinivasan, Jenolyn F Alexander, Wouter H Driessen, Fransisca Leonard, Hu Ye, Xuewu Liu, Wadih Arap, Renata Pasqualini, Mauro Ferrari, Biana Godin

Abstract read
In one paragraph

Article in Journal of materials chemistry. B, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Phage Therapy in the Era of Synthetic Biology.Cold Spring Harbor perspectives in biology · 2016
    Review
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Srimeenakshi SrinivasanThe Methodist Hospital Research Institute, Houston, Texas, USA.
Jenolyn F AlexanderThe Methodist Hospital Research Institute, Houston, Texas, USA.
Wouter H DriessenThe University of Texas MD Anderson Cancer Center, David H. Koch Center, Houston, Texas, USA.
Fransisca LeonardThe Methodist Hospital Research Institute, Houston, Texas, USA.
Hu YeThe Methodist Hospital Research Institute, Houston, Texas, USA.
Xuewu LiuThe Methodist Hospital Research Institute, Houston, Texas, USA.
Wadih ArapThe University of Texas MD Anderson Cancer Center, David H. Koch Center, Houston, Texas, USA.
Renata PasqualiniThe University of Texas MD Anderson Cancer Center, David H. Koch Center, Houston, Texas, USA.
Mauro FerrariThe Methodist Hospital Research Institute, Houston, Texas, USA.
Biana GodinThe Methodist Hospital Research Institute, Houston, Texas, USA.

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8M
Texas Center for Cancer NanomedicineU54CA151668 · NCI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI FERRARI, MAURO · 2010 to 2014
$12.4M
TRANS-NETWORK PROJECTSU54CA143837 · NCI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI FERRARI, MAURO · 2009 to 2014
$10.8M
NCI NIH HHS P30 CA016672NCI NIH HHS U54 CA143837NCI NIH HHS U54 CA151668
6 · The paper itself

Abstract

There has been extensive research on the use of nanovectors for cancer therapy. Targeted delivery of nanotherapeutics necessitates two important characteristics; the ability to accumulate at the disease locus after overcoming sequential biological barriers and the ability to carry a substantial therapeutic payload. Successful combination of the above two features is challenging, especially in solid porous materials where chemical conjugation of targeting entities on the particle surface will generally prevent successful loading of the therapeutic substance. In this study, we propose a novel strategy for decorating the surface of mesoporous silicon particles with targeting entities (bacteriophage) and gold nanoparticles (AuNP) while maintaining their payload carrying potential. The resulting Bacteriophage Associated Silicon Particles (BASP) demonstrates efficient encapsulation of macromolecules and therapeutic nanoparticles into the porous structures.

Identifiers

PMID24409342
PMCPMC3881592

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.