ArticlePloS one2014
Iron-dependent regulation of hepcidin in Hjv-/- mice: evidence that hemojuvelin is dispensable for sensing body iron levels.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
- Hypoferremic Response to Chronic Inflammation Is Controlled via the Hemojuvelin/Hepcidin/Ferroportin Axis and Does Not Involve Hepcidin-Independent Regulation of Fpn mRNA.American journal of hematology · 2025Article
- CardiacInternational journal of molecular sciences · 2023Article
- Genetic Iron Overload Hampers Development of Cutaneous Leishmaniasis in Mice.International journal of molecular sciences · 2023Article
- Article
- Role of Iron in Aging Related Diseases.Antioxidants (Basel, Switzerland) · 2022Article
- Hemojuvelin deficiency promotes liver mitochondrial dysfunction and predisposes mice to hepatocellular carcinoma.Communications biology · 2022Article
- Tissue-Specific Regulation of Ferroportin in Wild-Type and Hjv-/- Mice Following Dietary Iron Manipulations.Hepatology communications · 2021Article
- General Aspects of Metal Ions as Signaling Agents in Health and Disease.Biomolecules · 2020Review
- DNA methylation of hepatic iron sensing genes and the regulation of hepcidin expression.PloS one · 2018Article
- Inherited Disorders of Iron Overload.Frontiers in nutrition · 2018Review
- The immunophilin FKBP12 inhibits hepcidin expression by binding the BMP type I receptor ALK2 in hepatocytes.Blood · 2017Article
- Matriptase-2 suppresses hepcidin expression by cleaving multiple components of the hepcidin induction pathway.The Journal of biological chemistry · 2017Article
- Hereditary Hemochromatosis Predisposes Mice to Yersinia pseudotuberculosis Infection Even in the Absence of the Type III Secretion System.Frontiers in cellular and infection microbiology · 2016Article
- Renal iron overload in rats with diabetic nephropathy.Physiological reports · 2015Article
- Deficits of learning and memory in Hemojuvelin knockout mice.The Journal of veterinary medical science · 2015Article
- Hfe and Hjv exhibit overlapping functions for iron signaling to hepcidin.Journal of molecular medicine (Berlin, Germany) · 2015Article
- Salivary and serum biomarkers for the study of side effects of aripiprazole coprescribed with mirtazapine in rats.International journal of clinical and experimental medicine · 2015Article
- Article
- Electrophoretic mobility shift assay (EMSA) for the study of RNA-protein interactions: the IRE/IRP example.Journal of visualized experiments : JoVE · 2014Article
- Hemojuvelin and bone morphogenetic protein (BMP) signaling in iron homeostasis.Frontiers in pharmacology · 2014Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Hemojuvelin (Hjv) is a bone morphogenetic protein (BMP) co-receptor involved in the control of systemic iron homeostasis. Functional inactivation of Hjv leads to severe iron overload in humans and mice due to marked suppression of the iron-regulatory hormone hepcidin. To investigate the role of Hjv in body iron sensing, Hjv-/- mice and isogenic wild type controls were placed on a moderately low, a standard or a high iron diet for four weeks. Hjv-/- mice developed systemic iron overload under all regimens. Transferrin (Tf) was highly saturated regardless of the dietary iron content, while liver iron deposition was proportional to it. Hepcidin mRNA expression responded to fluctuations in dietary iron intake, despite the absence of Hjv. Nevertheless, iron-dependent upregulation of hepcidin was more than an order of magnitude lower compared to that seen in wild type controls. Likewise, iron signaling via the BMP/Smad pathway was preserved but substantially attenuated. These findings suggest that Hjv is not required for sensing of body iron levels and merely functions as an enhancer for iron signaling to hepcidin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.