ArticlePloS one2014
Salivary inflammatory mediator profiling and correlation to clinical disease markers in asthma.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Role of Salivary Biomarkers in Cystic Fibrosis: A Systematic Review.BioMed research international · 2022Pooled it
- Yogic breathing when compared to attention control reduces the levels of pro-inflammatory biomarkers in saliva: a pilot randomized controlled trial.BMC complementary and alternative medicine · 2016Trial
- Dentofacial Malocclusion and Salivary Biomarkers in Asthmatic Patients: A Scoping Review.International dental journal · 2026Article
- Biomarkers of pulmonary fibrosis in bronchoalveolar lavage fluid and saliva. Study methods and pathophysiological significance.Frontiers in medicine · 2026Review
- Prospective Associations Between Salivary Biomarkers of Inflammation and Body Mass Index in Adolescents.Obesity science & practice · 2025Article
- Selected Saliva-Derived Cytokines and Growth Factors Are Elevated in Pediatric Dentofacial Inflammation.International journal of molecular sciences · 2024Article
- Saliva-Based Protein Analysis in Pediatric Dentofacial Inflammation.Pediatric health, medicine and therapeutics · 2024Article
- Prediction of Asthma Exacerbations in Children.Journal of personalized medicine · 2023Review
- Multi-Omic Factors Associated with Frequency of Upper Respiratory Infections in Developing Infants.International journal of molecular sciences · 2023Article
- A narrative review of exploring potential salivary biomarkers in respiratory diseases: still on its way.Journal of thoracic disease · 2021Review
- The Predictive Role of Biomarkers and Genetics in Childhood Asthma Exacerbations.International journal of molecular sciences · 2021Review
- Longitudinal saliva omics responses to immune perturbation: a case study.Scientific reports · 2021Article
- Isolation and characterization of extracellular vesicles in saliva of children with asthma.Extracellular vesicles and circulating nucleic acids · 2021Article
- Salivary Cytokine Profile as a Possible Predictor of Autism Spectrum Disorder.Journal of clinical medicine · 2020Article
- Relationship between chemokines and T lymphocytes in the context of respiratory allergies (Review).Experimental and therapeutic medicine · 2020Review
- Determining the biological associates of acute cold pressor post-encoding stress effects on human memory: The role of salivary interleukin-1β.Brain, behavior, and immunity · 2019Article
- Asthma Biomarkers: Do They Bring Precision Medicine Closer to the Clinic?Allergy, asthma & immunology research · 2017Review
- Metabolomic similarities between bronchoalveolar lavage fluid and plasma in humans and mice.Scientific reports · 2017Observational
- Selected CC and CXC chemokines in children with atopic asthma.Postepy dermatologii i alergologii · 2016Article
- Potential Use of Salivary Markers for Longitudinal Monitoring of Inflammatory Immune Responses to Vaccination.Mediators of inflammation · 2016Review
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
rationaleThere is a need for a readily available, non-invasive source of biomarkers that predict poor asthma control.
objectivesWe sought to determine if there is an association between the salivary inflammatory profile and disease control in children and adults with asthma.
methodsIn this cross-sectional study, we collected demographic and clinical information from two independent populations at different sites, resulting in convenience samples of 58 pediatric and 122 adult urban asthmatics. Control was assessed by symptom questionnaire (children) and by Asthma Control Questionnaire and current exacerbation (adults). Saliva was collected in all subjects. We applied principal component analysis to a 10-plex panel of relevant inflammatory markers to characterize marker profiles and determined if profiles were associated with asthma control.
resultsThere were similar, strong correlations amongst biologically related markers in both populations: eosinophil-related: eotaxin-1/CCL11, RANTES/CCL5, and IL-5 (p<.001); myeloid/innate: IL-1β, IL-6, MCP-1/CCL2, and IL-8/CXCL8 (p<.001). The first three principal components captured ≥74% of variability across all ten analytes in both populations. In adults, the Principal Component 1 score, broadly reflective of all markers, but with greater weight given to myeloid/innate markers, was associated with Asthma Control Questionnaire score and exacerbation. The Principal Component 3 score, reflective of IP-10/CXCL10, was associated with current exacerbation. In children, the Principal Component 1, 2, and 3 scores were associated with recent asthma symptoms. The Principal Component 2 score, reflective of higher eosinophil markers, was inversely correlated with symptoms. The Principal Component 3 score was positively associated with all symptom outcomes.
conclusionThe salivary inflammatory profile is associated with disease control in children and adults with asthma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.