ArticlePloS one2014
A cost effectiveness analysis of salt reduction policies to reduce coronary heart disease in four Eastern Mediterranean countries.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 11 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
51 citing papers in PubMed, 11 syntheses or guidelines pooled it, 112 citations in OpenAlex.
- Policy models for preventative interventions in cardiometabolic diseases: a systematic review.BMC health services research · 2025Pooled it
- Modelling health and economic impact of nutrition interventions: a systematic review.European journal of clinical nutrition · 2023Pooled it
- Does health economics research align with the disease burden in the Middle East and North Africa region? A systematic review of economic evaluation studies on public health interventions.Global health research and policy · 2022Pooled it
- Disease-Related Costs Published in The Middle East and North Africa Region: Systematic Review and Analysis of Transferability.PharmacoEconomics · 2022Pooled it
- Salt Reduction Initiatives in the Eastern Mediterranean Region and Evaluation of Progress towards the 2025 Global Target: A Systematic Review.Nutrients · 2021Pooled it
- Monitoring and implementation of salt reduction initiatives in Africa: A systematic review.Journal of clinical hypertension (Greenwich, Conn.) · 2020Pooled it
- Cost-effectiveness of salt reduction to prevent hypertension and CVD: a systematic review.Public health nutrition · 2017Pooled it
- Systematic review of dietary salt reduction policies: Evidence for an effectiveness hierarchy?PloS one · 2017Pooled it
- A systematic review of economic evaluations of population-based sodium reduction interventions.PloS one · 2017Pooled it
- [Spanish Adaptation of the 2016 European Guidelines on Cardiovascular Disease Prevention in Clinical Practice].Revista espanola de salud publica · 2016Guideline
- Guideline
- Cost and cost-effectiveness of a school-based education program to reduce salt intake in children and their families in China.PloS one · 2017Trial
- Exploring Salt Reduction Strategies: Navigating Policy Implementation in the Middle East.Food science & nutrition · 2026Review
- Domain-specific knowledge on salt-related health risks and medical professional identity: implications for cardiovascular prevention.Cardiology journal · 2026Article
- Effective policies on prevention and control of cardiovascular diseases in different countries: A realistic review.Journal of education and health promotion · 2026Review
- The potential impact of policies and structural interventions in reducing cardiovascular disease and mortality: a systematic review of simulation-based studies.Health technology assessment (Winchester, England) · 2025Article
- An evaluation of the impacts of health insurance coverage on wealth stratification in some selected sub-Saharan countries.Health economics review · 2025Article
- Estimation of economic burden of high salt intake in cardiovascular disease attributed to hypertension in Iran.Cost effectiveness and resource allocation : C/E · 2025Article
- Evaluation of public health and economic impacts of dietary salt reduction initiatives on social security expenditures for cardiovascular disease control in Japan.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Review
- Public health economic modelling in evaluations of salt and/or alcohol policies: a systematic scoping review.BMC public health · 2025Article
Corrections and comments
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Authors and funding
16 authors at 9 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCoronary Heart Disease (CHD) is rising in middle income countries. Population based strategies to reduce specific CHD risk factors have an important role to play in reducing overall CHD mortality. Reducing dietary salt consumption is a potentially cost-effective way to reduce CHD events. This paper presents an economic evaluation of population based salt reduction policies in Tunisia, Syria, Palestine and Turkey. METHODS AND
findingsThree policies to reduce dietary salt intake were evaluated: a health promotion campaign, labelling of food packaging and mandatory reformulation of salt content in processed food. These were evaluated separately and in combination. Estimates of the effectiveness of salt reduction on blood pressure were based on a literature review. The reduction in mortality was estimated using the IMPACT CHD model specific to that country. Cumulative population health effects were quantified as life years gained (LYG) over a 10 year time frame. The costs of each policy were estimated using evidence from comparable policies and expert opinion including public sector costs and costs to the food industry. Health care costs associated with CHDs were estimated using standardized unit costs. The total cost of implementing each policy was compared against the current baseline (no policy). All costs were calculated using 2010 PPP exchange rates. In all four countries most policies were cost saving compared with the baseline. The combination of all three policies (reducing salt consumption by 30%) resulted in estimated cost savings of $235,000,000 and 6455 LYG in Tunisia; $39,000,000 and 31674 LYG in Syria; $6,000,000 and 2682 LYG in Palestine and $1,3000,000,000 and 378439 LYG in Turkey.
conclusionDecreasing dietary salt intake will reduce coronary heart disease deaths in the four countries. A comprehensive strategy of health education and food industry actions to label and reduce salt content would save both money and lives.
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Registered trials
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