ReviewFrontiers in immunology2013
Debug Your Bugs - How NLRs Shape Intestinal Host-Microbe Interactions.
Review in Frontiers in immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- The Dual Role of the Airway Epithelium in Asthma: Active Barrier and Regulator of Inflammation.Cells · 2023Review
- Review
- NLR and Intestinal Dysbiosis-Associated Inflammatory Illness: Drivers or Dampers?Frontiers in immunology · 2020Review
- Receptors Mediating Host-Microbiota Communication in the Metaorganism: The Invertebrate Perspective.Frontiers in immunology · 2020Review
- Differential expression of immune receptors in two marine sponges upon exposure to microbial-associated molecular patterns.Scientific reports · 2018Article
- Do fungi have an innate immune response? An NLR-based comparison to plant and animal immune systems.PLoS pathogens · 2017Review
- Review
- The innate immune function of airway epithelial cells in inflammatory lung disease.The European respiratory journal · 2015Review
- Article
- Editorial: NLR-Protein Functions in Immunity.Frontiers in immunology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The host's ability to discriminate friend and foe and to establish a precise homeostasis with its associated microbiota is crucial for its survival and fitness. Among the mediators of intestinal host-microbe interactions, NOD-like receptor (NLR) proteins take center stage. They are present in the epithelial lining and innate immune cells that constantly monitor microbial activities at the intestinal barrier. Dysfunctional NLRs predispose to intestinal inflammation as well as sensitization to extra-intestinal immune-mediated diseases and are linked to the alteration of microbial communities. Here, we review advances in our understanding of their reciprocal relationship in the regulation of intestinal homeostasis and implications for intestinal health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.