Evidence map›Paper›PMID 24409157›Full record

ReviewFrontiers in psychiatry2014

A systematic review of cognitive function in first-episode psychosis, including a discussion on childhood trauma, stress, and inflammation.

Monica Aas, Paola Dazzan, Valeria Mondelli, Ingrid Melle, Robin M Murray, Carmine M Pariante

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
100citing papers in PubMed, 13 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

100 citing papers in PubMed, 13 syntheses or guidelines pooled it.

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  5. Cognitive impairment in people with schizophrenia: an umbrella review.European archives of psychiatry and clinical neuroscience · 2022
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  6. European Psychiatric Association guidance on assessment of cognitive impairment in schizophrenia.European psychiatry : the journal of the Association of European Psychiatrists · 2022
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  11. Β-Amyloid Burden is Not Associated with Cognitive Impairment in Schizophrenia: A Systematic Review.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2016
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  19. Cognitive and clinical profiles in first-episode psychosis and their relationship with functional outcomes.The British journal of psychiatry : the journal of mental science · 2026
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40 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Monica AasDivision of Mental Health and Addiction, Institute of Clinical Medicine, University of Oslo , Oslo , Norway ; NORMENT, K.G. Jebsen Psychosis Research Unit, Division of Mental Health and Addiction, Oslo University Hospital , Oslo , Norway.
Paola DazzanDepartment of Psychosis Studies, Institute of Psychiatry, King's College London , London , UK ; NIHR Biomedical Research Centre for Mental Health, South London and Maudsley NHS Foundation Trust and Institute of Psychiatry, King's College London , London , UK.
Valeria MondelliDepartment of Psychological Medicine, Institute of Psychiatry, King's College London , London , UK.
Ingrid MelleDivision of Mental Health and Addiction, Institute of Clinical Medicine, University of Oslo , Oslo , Norway ; NORMENT, K.G. Jebsen Psychosis Research Unit, Division of Mental Health and Addiction, Oslo University Hospital , Oslo , Norway.
Robin M MurrayDepartment of Psychosis Studies, Institute of Psychiatry, King's College London , London , UK ; NIHR Biomedical Research Centre for Mental Health, South London and Maudsley NHS Foundation Trust and Institute of Psychiatry, King's College London , London , UK.
Carmine M ParianteNIHR Biomedical Research Centre for Mental Health, South London and Maudsley NHS Foundation Trust and Institute of Psychiatry, King's College London , London , UK ; Department of Psychological Medicine, Institute of Psychiatry, King's College London , London , UK.

Funding

Medical Research Council G108/603Medical Research Council MR/J002739/1MRF_ C0439
6 · The paper itself

Abstract

objectiveTo carry out a systematic review of the literature addressing cognitive functions in first-episode psychosis (FEP), divided into domains. Although this is not a full "cognitive-genetics-in-schizophrenia review," we will also include putative ideas of mechanism(s) behind these impairments, focusing on how early stress, and genetic vulnerability may moderate cognitive function in psychosis.

methodRelevant studies were identified via computer literature searches for research published up to and including January 2013, only case-control studies were included for the neurocognitive meta-analysis.

resultsPatients with FEP present global cognitive impairment compared to healthy controls. The largest effect size was observed for verbal memory (Cohen's d effect size = 2.10), followed by executive function (effect size = 1.86), and general IQ (effect size = 1.71). However, effect sizes varied between studies.

conclusionCognitive impairment across domains, up to severe level based on Cohen's effect size, is present already in FEP studies. However, differences in levels of impairment are observed between studies, as well as within domains, indicating that further consolidation of cognitive impairment over the course of illness may be present. Cognitive abnormalities may be linked to a neurodevelopmental model including increased sensitivity to the negative effect of stress, as well as genetic vulnerability. More research on this field is needed.

Indexed as

cognitionfirst-episode psychosisgenes × environment interactionsphysiologicalreview of literaturestress

Identifiers

PMID24409157
PMCPMC3884147

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.