ArticleFrontiers in behavioral neuroscience2013
Sex differences in stress-induced social withdrawal: role of brain derived neurotrophic factor in the bed nucleus of the stria terminalis.
Article in Frontiers in behavioral neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 2 of them syntheses that pooled it.
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Who cites it
65 citing papers in PubMed, 2 syntheses or guidelines pooled it, 93 citations in OpenAlex.
- Comparing the effect of fluoxetine, escitalopram, and sertraline, on the level of BDNF and depression in preclinical and clinical studies: a systematic review.European journal of clinical pharmacology · 2024Pooled it
- Coordination of social behaviors by the bed nucleus of the stria terminalis.The European journal of neuroscience · 2022Pooled it
- Neural basis of social hierarchy across species.Nature reviews. Neuroscience · 2026Review
- Oxytocin neurons in the anterior and posterior paraventricular nucleus have distinct behavioral functions and electrophysiological profiles.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Effects of partial cage dividers on animal welfare and social behavior in California mice (Applied animal behaviour science · 2026Article
- CRISPR-mediated knockdown of oxytocin receptor in extended amygdala reduces stress-induced social avoidance in female California mice.Hormones and behavior · 2025Article
- Oxytocin neurons in the anterior and posterior paraventricular nucleus have distinct behavioral functions and electrophysiological profiles.bioRxiv : the preprint server for biology · 2025Article
- CRISPR-mediated knockdown of oxytocin receptor in extended amygdala reduces stress-induced social avoidance in female California mice.bioRxiv : the preprint server for biology · 2025Article
- Acute and vicarious effects of social defeat stress on social behaviour in California mice,Animal behaviour · 2025Article
- Serum BDNF Increase After 9-Month Contemplative Mental Training Is Associated With Decreased Cortisol Secretion and Increased Dentate Gyrus Volume: Evidence From a Randomized Clinical Trial.Biological psychiatry global open science · 2025Article
- Characterization of transcriptional profiles associated with stress-induced neuronal activation in Arc-GFP mice.Molecular psychiatry · 2024Article
- Prosocial reputation and stress among contemporary hunter-gatherers: the Hadza case.Scientific reports · 2024Article
- Leveraging the unique social organization of California mice to study circuit-specific effects of oxytocin on behavior.Hormones and behavior · 2024Review
- Sexual differentiation of neural mechanisms of stress sensitivity during puberty.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Comparative Transcriptional Analyses in the Nucleus Accumbens Identifies RGS2 as a Key Mediator of Depression-Related Behavior.Biological psychiatry · 2022Article
- Synaptic ensembles between raphe and DScience advances · 2022Article
- Oxytocin receptor behavioral effects and cell types in the bed nucleus of the stria terminalis.Hormones and behavior · 2022Article
- Quantifying Sex Differences in Behavior in the Era of "Big" Data.Cold Spring Harbor perspectives in biology · 2022Review
- Toward the explainability, transparency, and universality of machine learning for behavioral classification in neuroscience.Current opinion in neurobiology · 2022Review
- Acute administration of fluoxetine increases social avoidance and risk assessment behaviors in a sex- and social stress-dependent manner in Syrian hamsters (Mesocricetus auratus).Pharmacology, biochemistry, and behavior · 2022Article
5 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Depression and anxiety disorders are more common in women than men, and little is known about the neurobiological mechanisms that contribute to this disparity. Recent data suggest that stress-induced changes in neurotrophins have opposing effects on behavior by acting in different brain networks. Social defeat has been an important approach for understanding neurotrophin action, but low female aggression levels in rats and mice have limited the application of these methods primarily to males. We examined the effects of social defeat in monogamous California mice (Peromyscus californicus), a species in which both males and females defend territories. We demonstrate that defeat stress increases mature brain-derived neurotrophic factor (BDNF) protein but not mRNA in the bed nucleus of the stria terminalis (BNST) in females but not males. Changes in BDNF protein were limited to anterior subregions of the BNST, and there were no changes in the adjacent nucleus accumbens (NAc). The effects of defeat on social withdrawal behavior and BDNF were reversed by chronic, low doses of the antidepressant sertraline. However, higher doses of sertraline restored social withdrawal and elevated BDNF levels. Acute treatment with a low dose of sertraline failed to reverse the effects of defeat. Infusions of the selective tyrosine-related kinase B receptor (TrkB) antagonist ANA-12 into the anterior BNST specifically increased social interaction in stressed females but had no effect on behavior in females naïve to defeat. These results suggest that stress-induced increases in BDNF in the anterior BNST contribute to the exaggerated social withdrawal phenotype observed in females.
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