ArticleFrontiers in behavioral neuroscience2013
Transcranial slow oscillation stimulation during NREM sleep enhances acquisition of the radial maze task and modulates cortical network activity in rats.
Article in Frontiers in behavioral neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 41 citations in OpenAlex.
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- Influence of Repeated Exposure to Neonatal Isoflurane on Sleep Architecture and Neuronal Delta and Theta Oscillations in Adolescent Rats.Anesthesia and analgesia · 2025Article
- Melatonin Reduced Hyperexcitability and Enhanced Sleep Oscillations in the Hippocampus and Prefrontal Cortex of Aged Male Rats.Neurochemical research · 2025Article
- Effectiveness of Anodal otDCS Following with Anodal tDCS Rather than tDCS Alone for Increasing of Relative Power of Intrinsic Matched EEG Bands in Rat Brains.Brain sciences · 2022Article
- Neonatal Isoflurane Does Not Affect Sleep Architecture and Minimally Alters Neuronal Beta Oscillations in Adolescent Rats.Frontiers in behavioral neuroscience · 2021Article
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- Using animal models to improve the design and application of transcranial electrical stimulation in humans.Current behavioral neuroscience reports · 2018Article
- Neurobiological correlates of state-dependent context fear.Learning & memory (Cold Spring Harbor, N.Y.) · 2017Article
- Enhancement of synchronized activity between hippocampal CA1 neurons during initial storage of associative fear memory.The Journal of physiology · 2017Article
- Sleep-dependent memory consolidation and its implications for psychiatry.Journal of neural transmission (Vienna, Austria : 1996) · 2017Review
- The Roles of Cortical Slow Waves in Synaptic Plasticity and Memory Consolidation.Frontiers in neural circuits · 2017Article
- Levels of Interference in Long and Short-Term Memory Differentially Modulate Non-REM and REM Sleep.Sleep · 2016Article
- Loss of promoter IV-driven BDNF expression impacts oscillatory activity during sleep, sensory information processing and fear regulation.Translational psychiatry · 2016Article
- Hippocampal sharp wave-ripple: A cognitive biomarker for episodic memory and planning.Hippocampus · 2015Review
- Sleep for cognitive enhancement.Frontiers in systems neuroscience · 2014Review
- Transcranial direct current stimulation for memory enhancement: from clinical research to animal models.Frontiers in systems neuroscience · 2014Review
- Endogenous cortical oscillations constrain neuromodulation by weak electric fields.Brain stimulationArticle
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Slow wave sleep, hallmarked by the occurrence of slow oscillations (SO), plays an important role for the consolidation of hippocampus-dependent memories. Transcranial stimulation by weak electric currents oscillating at the endogenous SO frequency (SO-tDCS) during post-learning sleep was previously shown by us to boost SO activity and improve the consolidation of hippocampus-dependent memory in human subjects. Here, we aimed at replicating and extending these results to a rodent model. Rats were trained for 12 days at the beginning of their inactive phase in the reference memory version of the radial arm maze. In a between subjects design, animals received SO-tDCS over prefrontal cortex (PFC) or sham stimulation within a time frame of 1 h during subsequent non-rapid eye movement (NREM) sleep. Applied over multiple daily sessions SO-tDCS impacted cortical network activity as measured by EEG and behavior: at the EEG level, SO-tDCS enhanced post-stimulation upper delta (2-4 Hz) activity whereby the first stimulations of each day were preferentially affected. Furthermore, commencing on day 8, SO-tDCS acutely decreased theta activity indicating long-term effects on cortical networks. Behaviorally, working memory for baited maze arms was enhanced up to day 4, indicating enhanced consolidation of task-inherent rules, while reference memory errors did not differ between groups. Taken together, we could show here for the first time an effect of SO-tDCS during NREM sleep on cognitive functions and on cortical activity in a rodent model.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.