ReviewFrontiers in cellular neuroscience2014
Recurrent synapses and circuits in the CA3 region of the hippocampus: an associative network.
Review in Frontiers in cellular neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.
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Who cites it
79 citing papers in PubMed, 127 citations in OpenAlex.
- Exercise-Induced Activation of IGF-1/mTOR Signaling and Hippocampal BDNF/PGC-1α Expression Reverses Age-Related Motor Decline.International neurourology journal · 2026Article
- Unique deficits in place coding across subfields of the hippocampus in a mouse model of temporal lobe epilepsy.Epilepsia · 2026Article
- Postoperative Impairment of GluA2 Ttrafficking in CA3 Induces Memory Consolidation Deficits in Aged Mice by Disrupting SPW-R in CA1.Journal of molecular neuroscience : MN · 2026Article
- Single-nucleus profiling reveals a core disease signature and cell type-specific vulnerabilities in early Rett syndrome.Science advances · 2026Article
- Ibogalogs induce antiseizure activity in rodents by a mechanism involving 5-HTBiochemical pharmacology · 2026Article
- Balancing Stability and Flow in Hippocampal Networks via Inductive Bias and Learned Symmetry Breaking.bioRxiv : the preprint server for biology · 2026Article
- Developmental emergence of sparse and structured synaptic connectivity in the hippocampal CA3 memory circuit.Nature communications · 2026Article
- Astrocyte-mediated higher-order control of synaptic plasticity.Communications biology · 2026Article
- A spatially discretized convolutional neural mass model for studying meso-scale spatio-temporal transformations in the rat hippocampus.Research square · 2026Article
- Neuronal APOE4-induced early hippocampal network hyperexcitability in Alzheimer's disease pathogenesis.Nature aging · 2026Article
- Mechanobiology of hippocampal neurogenesis: directing neural stem cell fate through physical cues.Frontiers in molecular neuroscience · 2026Review
- Slow synaptic plasticity from the hippocampus underlies gradual mapping and fragmentation of novel spaces by grid cells.bioRxiv : the preprint server for biology · 2025Article
- Aberrant hippocampal gamma oscillations in a mouse model of fragile X syndrome: insights from in vitro slice models.Molecular autism · 2025Article
- Hippocampal sequences represent working memory and implicit timing.Cell reports · 2025Article
- A circuit from the basolateral amygdala to hippocampal CA3 regulates social behavior.Current biology : CB · 2025Article
- Optical Recordings of Unitary Synaptic Connections Reveal High and Random Local Connectivity between CA3 Pyramidal Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Blood volume sensitive laminar fMRI with VASO in human hippocampus: Capabilities and biophysical challenges at clinical 7T scanners.bioRxiv : the preprint server for biology · 2025Article
- Astrocytopathy Is Associated with CA1 Synaptic Dysfunction in a Mouse Model of Down Syndrome.Cells · 2025Article
- Time Makes Space: Emergence of Place Fields in Networks Encoding Temporally Continuous Sensory Experiences.bioRxiv : the preprint server for biology · 2025Article
- Article
19 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
In the CA3 region of the hippocampus, pyramidal cells excite other pyramidal cells and interneurons. The axons of CA3 pyramidal cells spread throughout most of the region to form an associative network. These connections were first drawn by Cajal and Lorente de No. Their physiological properties were explored to understand epileptiform discharges generated in the region. Synapses between pairs of pyramidal cells involve one or few release sites and are weaker than connections made by mossy fibers on CA3 pyramidal cells. Synapses with interneurons are rather effective, as needed to control unchecked excitation. We examine contributions of recurrent synapses to epileptiform synchrony, to the genesis of sharp waves in the CA3 region and to population oscillations at theta and gamma frequencies. Recurrent connections in CA3, as other associative cortices, have a lower connectivity spread over a larger area than in primary sensory cortices. This sparse, but wide-ranging connectivity serves the functions of an associative network, including acquisition of neuronal representations as activity in groups of CA3 cells and completion involving the recall from partial cues of these ensemble firing patterns.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.