ArticleSaudi journal of ophthalmology : official journal of the Saudi Ophthalmological Society2013
Sequential, non-arteritic anterior ischemic optic neuropathy in patients taking sildenafil: a report of ten cases.
Article in Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological Society, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Non-invasive positive airway pressure therapy for improving erectile dysfunction in men with obstructive sleep apnoea.The Cochrane database of systematic reviews · 2021Pooled it
- Glucagon-Like Peptide-1 Analogs Associated with a Reduced Risk of Legal Blindness in Type 2 Diabetics with Cardiovascular Risks.Clinical ophthalmology (Auckland, N.Z.) · 2026Article
- Review
- Non-arteritic anterior ischaemic optic neuropathy (NA-AION) and COVID-19 vaccination.BMJ case reports · 2022Article
- Identification of a new selective dopamine D4 receptor ligand.Bioorganic & medicinal chemistry · 2014Article
- Phosphodiesterase Type 5 Inhibitors and Visual Side Effects: A Narrative Review.Journal of ophthalmic & vision researchReview
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aim/purposeTo present a summary of 10 cases of non-arteritic anterior ischemic optic neuropathy (NAION) in patients who received phosphodiesterase type 5 (PDE-5) inhibitors.
methodsA case series of 10 patients who, after regular intake of Sildenafil, presented with a first episode of NAION in one eye. NAION was diagnosed based on the following criteria: acute, painless, unilateral loss of vision, fundus features consistent with NAION and exclusion of other possible causes.
resultsDespite the initial adverse event (first episode of NAION), all of these patients continued to use the medication and developed a second episode of NAION in the contralateral eye. Only one of the 10 patients presented with bilateral simultaneous NAION.
conclusionThis largest case series published to date, reinforces the general consensus that PDE-5 inhibitors are contraindicated in patients with a history of unilateral NAION.
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