ArticleJournal of physical therapy science2013
Effect of Lactate Accumulation during Exercise-induced Muscle Fatigue on the Sensorimotor Cortex.
Article in Journal of physical therapy science, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 70 citations in OpenAlex.
- Trial
- Physical and cognitive contributions to fatigue perception: The interplay between local muscle fatigue and sensory prediction error.iScience · 2026Article
- Repeated Sprint Performance and Inter-Limb Asymmetry in Elite Female Sprinters: A Study of Lactate Dynamics and Lower Limb Muscle Activity.Journal of functional morphology and kinesiology · 2025Article
- Brain derived neurotrophic factor and secreted amyloid precursor protein-α response to moderate and high intensity exercise.Physiological reports · 2025Article
- A neurometabolic mechanism involving dmPFC/dACC lactate in physical effort-based decision-making.Molecular psychiatry · 2025Article
- Verification of fingertip blood lactate measurement as an index of muscle fatigue recovery.Journal of physical therapy science · 2025Article
- Effects of asymmetric load bench press offset training on muscle activation levels and exercise-induced fatigue in collegiate bodybuilders.Frontiers in physiology · 2025Article
- The effects of blood flow restriction training on post activation potentiation and fatigue level: systematic review with meta-analysis.Frontiers in physiology · 2025Review
- A New Approach to Noninvasive-Prolonged Fatigue Identification Based on Surface EMG Time-Frequency and Wavelet Features.Journal of healthcare engineering · 2023Article
- Article
- Impaired Muscle Mitochondrial Function in Familial Partial Lipodystrophy.The Journal of clinical endocrinology and metabolism · 2022Observational
- Tipping the balance between erythroid cell differentiation and induction of anemia in response to the inflammatory pathology associated with chronic trypanosome infections.Frontiers in immunology · 2022Article
- Swimming Improves Memory and Antioxidant Defense in an Animal Model of Duchenne Muscular Dystrophy.Molecular neurobiology · 2021Article
- Adapted Chester Step Test Can Have Maximal Response Characteristics for the Assessment of Exercise Capacity in Young Women.Healthcare (Basel, Switzerland) · 2021Article
- A Botanical Product Containing Cistanche and Ginkgo Extracts Potentially Improves Chronic Fatigue Syndrome Symptoms in Adults: A Randomized, Double-Blind, and Placebo-Controlled Study.Frontiers in nutrition · 2021Article
- Exploring Associations Between Metabolites and Symptoms of Fatigue, Depression and Pain in Women With Fibromyalgia.Biological research for nursing · 2021Article
- Muscle Fatigue Revisited - Insights From Optically Pumped Magnetometers.Frontiers in physiology · 2021Article
- Effect of Aerobic Physical Exercise in an Animal Model of Duchenne Muscular Dystrophy.Journal of molecular neuroscience : MN · 2020Article
- Brain activity during self-paced vs. fixed protocols in graded exercise testing.Experimental brain research · 2019Article
- The brain behaves as a muscle?Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
[Purpose] During exercise, skeletal muscle motor units are recruited based on afferent sensory input following peripheral metabolic by-product accumulation. The purpose of this study was to investigate whether lactate plays a role in conveying fatigue-related information to the brain. [Subjects] Eleven healthy adults participated in this study. [Methods] Subjects performed handgrip exercises at 10%, 30%, and 50% maximal voluntary contraction for 120 s. They were monitored for brachial artery blood pressure, respiratory quotient, muscle fatigue (integrated electromyogram, median power frequency), blood lactate levels, muscle blood flow, and brain activity. [Results] The handgrip exercise protocol caused significant muscle fatigue based on 28% and 37% reductions in median power frequency detected at 30% and 50% maximal voluntary contraction, respectively. Subjects exhibited intensity-dependent increases in blood pressure, respiratory quotient, muscle blood flow, and circulating lactate concentrations. Furthermore, brain activity increased at 30% and 50% maximal voluntary contraction. Multiple regression analysis identified muscle blood flow at 30% maximal voluntary contraction and lactate at 50% maximal voluntary contraction with standardized partial regression coefficients of -0.64 and 0.75, respectively. [Conclusion] These data suggest that blood lactate concentration and muscle blood flow, which reflect muscle metabolism, may convey load intensity information to the brain during muscle fatigue.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.