ArticleJournal of applied physiology (Bethesda, Md. : 1985)2014
A computational model of the response of adherent cells to stretch and changes in substrate stiffness.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 44 citations in OpenAlex.
- Unravelling the Distinct Phenotype and Mechanosensitive Properties of Different Tendon Cell Populations.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Stiffening of the extracellular matrix is a sufficient condition for airway hyperreactivity.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Article
- Intercellular communication controls agonist-induced calcium oscillations independently of gap junctions in smooth muscle cells.Science advances · 2020Article
- Intercellular Adhesion Stiffness Moderates Cell Decoupling as a Function of Substrate Stiffness.Biophysical journal · 2020Article
- Modeling of Mechanosensing Mechanisms Reveals Distinct Cell Migration Modes to Emerge From Combinations of Substrate Stiffness and Adhesion Receptor-Ligand Affinity.Frontiers in bioengineering and biotechnology · 2020Article
- Extracellular matrix stiffness regulates human airway smooth muscle contraction by altering the cell-cell coupling.Scientific reports · 2019Article
- Transition From Phasic to Tonic Contractility in Airway Smooth Muscle After Birth: An Experimental and Computational Modeling Study.Journal of engineering and science in medical diagnostics and therapy · 2019Article
- Modelling Cell Origami via a Tensegrity Model of the Cytoskeleton in Adherent Cells.Applied bionics and biomechanics · 2019Article
- Blood pressure-induced physiological strain variability modulates wall structure and function in aorta rings.Physiological measurement · 2018Article
- Emergent mechanics of actomyosin drive punctuated contractions and shape network morphology in the cell cortex.PLoS computational biology · 2018Article
- Regulation of Mitochondrial Structure and Dynamics by the Cytoskeleton and Mechanical Factors.International journal of molecular sciences · 2017Review
- Actomyosin meshwork mechanosensing enables tissue shape to orient cell force.Nature communications · 2017Article
- The Nuclear Option: Evidence Implicating the Cell Nucleus in Mechanotransduction.Journal of biomechanical engineering · 2017Review
- Regulatory Roles of Fluctuation-Driven Mechanotransduction in Cell Function.Physiology (Bethesda, Md.) · 2016Review
- Homeostatic maintenance via degradation and repair of elastic fibers under tension.Scientific reports · 2016Article
- Multiscale mechanobiology: computational models for integrating molecules to multicellular systems.Integrative biology : quantitative biosciences from nano to macro · 2015Review
- Fluctuation-driven mechanotransduction regulates mitochondrial-network structure and function.Nature materials · 2015Article
- Can breathing-like pressure oscillations reverse or prevent narrowing of small intact airways?Journal of applied physiology (Bethesda, Md. : 1985) · 2015Article
- Matrix stiffness-modulated proliferation and secretory function of the airway smooth muscle cells.American journal of physiology. Lung cellular and molecular physiology · 2015Article
- Cells as liquid motors: mechanosensitivity emerges from collective dynamics of actomyosin cortex.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Cells in the body exist in a dynamic mechanical environment where they are subject to mechanical stretch as well as changes in composition and stiffness of the underlying extracellular matrix (ECM). However, the underlying mechanisms by which cells sense and adapt to their dynamic mechanical environment, in particular to stretch, are not well understood. In this study, we hypothesized that emergent phenomena at the level of the actin network arising from active structural rearrangements driven by nonmuscle myosin II molecular motors play a major role in the cellular response to both stretch and changes in ECM stiffness. To test this hypothesis, we introduce a simple network model of actin-myosin interactions that links active self-organization of the actin network to the stiffness of the network and the traction forces generated by the network. We demonstrate that such a network replicates not only the effect of changes in substrate stiffness on cellular traction and stiffness and the dependence of rate of force development by a cell on the stiffness of its substrate, but also explains the physical response of adherent cells to transient and cyclic stretch. Our results provide strong indication that network phenomena governed by the active reorganization of the actin-myosin structure plays an important role in cellular mechanosensing and response to both changes in ECM stiffness and externally applied mechanical stretch.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.