ArticleCerebral cortex (New York, N.Y. : 1991)2015
Analysis of synaptic gene expression in the neocortex of primates reveals evolutionary changes in glutamatergic neurotransmission.
Article in Cerebral cortex (New York, N.Y. : 1991), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
- Kynurenic acid signaling expands in human and nonhuman primates and impairs dorsolateral prefrontal cortical cognition that is key to mental illness.Molecular psychiatry · 2026Article
- Inflammatory mechanisms underlying early Alzheimer's disease pathology: evidence from the aging rhesus macaque brain.Frontiers in cellular neuroscience · 2026Review
- Article
- Higher dopamine D1 receptor expression in prefrontal parvalbumin neurons underlies higher distractibility in marmosets versus macaques.Communications biology · 2025Article
- Human-specific gene expansions contribute to brain evolution.bioRxiv : the preprint server for biology · 2025Article
- Dysregulated calcium signaling in the aged primate association cortices: vulnerability to Alzheimer's disease neuropathology.Frontiers in aging neuroscience · 2025Review
- Contrasting patterns of extrasynaptic NMDAR-GluN2B expression in macaque subgenual cingulate and dorsolateral prefrontal cortices.Frontiers in neuroanatomy · 2025Article
- Evolution of Glutamate Metabolism viaInternational journal of molecular sciences · 2024Review
- The meso-connectomes of mouse, marmoset, and macaque: network organization and the emergence of higher cognition.Cerebral cortex (New York, N.Y. : 1991) · 2024Review
- Glutamate-specific gene linked to human brain evolution enhances synaptic plasticity and cognitive processes.iScience · 2024Article
- Astrocytes Drive Divergent Metabolic Gene Expression in Humans and Chimpanzees.Genome biology and evolution · 2024Article
- Studies of aging nonhuman primates illuminate the etiology of early-stage Alzheimer's-like neuropathology: An evolutionary perspective.American journal of primatology · 2021Review
- NMDAR Neurotransmission Needed for Persistent Neuronal Firing: Potential Roles in Mental Disorders.Frontiers in psychiatry · 2021Review
- Transgenic Mice Carrying GLUD2 as a Tool for Studying the Expressional and the Functional Adaptation of this Positive Selected Gene in Human Brain Evolution.Neurochemical research · 2019Article
- Blockade of glutamate receptor ameliorates lipopolysaccharide-induced sepsis through regulation of neuropeptides.Bioscience reports · 2018Article
- Comparative Hippocampal Synaptic Proteomes of Rodents and Primates: Differences in Neuroplasticity-Related Proteins.Frontiers in molecular neuroscience · 2018Article
- Ultrastructural analysis of parvalbumin synapses in human dorsolateral prefrontal cortex.The Journal of comparative neurology · 2017Article
- Evidence of a Conserved Molecular Response to Selection for Increased Brain Size in Primates.Genome biology and evolution · 2017Article
- Interaction effect between handedness and CNTNAP2 polymorphism (rs7794745 genotype) on voice-specific frontotemporal activity in healthy individuals: an fMRI study.Frontiers in behavioral neuroscience · 2015Article
- Humans and great apes share increased neocortical neuropeptide Y innervation compared to other haplorhine primates.Frontiers in human neuroscience · 2014Article
Corrections and comments
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Authors and funding
9 authors at 8 institutions in 1 country.
Funding
Abstract
Increased relative brain size characterizes the evolution of primates, suggesting that enhanced cognition plays an important part in the behavioral adaptations of this mammalian order. In addition to changes in brain anatomy, cognition can also be regulated by molecular changes that alter synaptic function, but little is known about modifications of synapses in primate brain evolution. The aim of the current study was to investigate the expression patterns and evolution of 20 synaptic genes from the prefrontal cortex of 12 primate species. The genes investigated included glutamate receptors, scaffolding proteins, synaptic vesicle components, as well as factors involved in synaptic vesicle release and structural components of the nervous system. Our analyses revealed that there have been significant changes during primate brain evolution in the components of the glutamatergic signaling pathway in terms of gene expression, protein expression, and promoter sequence changes. These results could entail functional modifications in the regulation of specific genes related to processes underlying learning and memory.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.