ArticleCerebral cortex (New York, N.Y. : 1991)2015
Human thalamus regulates cortical activity via spatially specific and structurally constrained phase-amplitude coupling.
Article in Cerebral cortex (New York, N.Y. : 1991), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed.
- Increased thalamic resting-state connectivity as a core driver of LSD-induced hallucinations.Acta psychiatrica Scandinavica · 2017Trial
- Pallidal deep brain stimulation modulates excessive cortical high β phase amplitude coupling in Parkinson disease.Brain stimulationTrial
- Thalamocortical orchestration of human theory of mind.bioRxiv : the preprint server for biology · 2026Article
- Nucleus-level thalamic organization anchors multimodal signatures of thalamocortical maturation.bioRxiv : the preprint server for biology · 2026Article
- Whisker stimulation reinforces a resting-state network in the barrel cortex: Nested oscillations and avalanches.PLoS computational biology · 2026Article
- Stroke and motor outcomes are associated with regional and age-specific changes in periodic and aperiodic cortical activity.Experimental physiology · 2026Article
- Functional connectivity in infants' visual cortex and its links to motion processing and autism.Scientific reports · 2026Article
- Untangling cross-regional cross-frequency coupling in dynamic neural oscillations.Journal of neural engineering · 2025Article
- Article
- Dissociation between Simple and Complex Speech Motor Tasks within the Bilateral Motor Thalamus.eNeuro · 2025Article
- Resting-State EEG Oscillations in Amyotrophic Lateral Sclerosis (ALS): Toward Mechanistic Insights and Clinical Markers.Journal of clinical medicine · 2025Review
- Altered functional connectivity strength between structurally and functionally affected brain regions in visual snow syndrome.Brain communications · 2025Article
- Criticality supports cross-frequency cortical-thalamic information transfer during conscious states.eLife · 2024Article
- Neural mechanisms of domain-general inhibitory control.Trends in cognitive sciences · 2023Review
- The impact of the human thalamus on brain-wide information processing.Nature reviews. Neuroscience · 2023Review
- Thalamic bursts modulate cortical synchrony locally to switch between states of global functional connectivity in a cognitive task.PLoS computational biology · 2022Article
- Basal Ganglia and Thalamic Contributions to Language Function: Insights from A Parallel Distributed Processing Perspective.Neuropsychology review · 2021Review
- Eye movement characteristics provide an objective measure of visual processing changes in patients with visual snow syndrome.Scientific reports · 2021Article
- The Psychiatric Symptomology of Visual Snow Syndrome.Frontiers in neurology · 2021Article
- Neurodevelopmental disorders: 2021 update.Free neuropathology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Although the thalamus is believed to regulate and coordinate cortical activity both within and across functional regions, such as motor and visual cortices, direct evidence for such regulation and the mechanism of regulation remains poorly described. Using simultaneous invasive recordings of cortical and thalamic electrophysiological activity in 2 awake and spontaneously behaving human subjects, we provide direct evidence of thalamic regulation of cortical activity through a mechanism of phase-amplitude coupling (PAC), in which the phase of low frequency oscillations regulates the amplitude of higher frequency oscillations. Specifically, we show that cortical PAC between the theta phase and beta amplitude is spatially dependent on and time variant with the magnitude of thalamocortical theta coherence. Moreover, using causality analysis and MR diffusion tractography, we provide evidence that thalamic theta activity drives cortical theta oscillations and PAC across structures and that these thalamocortical relationships are structurally constrained by anatomic pathways. This relationship allows for new evidence of thalamocortical PAC. Given the diffuse connectivity of the thalamus with the cerebral cortex, thalamocortical PAC may play an important role in addressing the binding problem, including both integration and segregation of information within and across cortical areas.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.