ArticleCerebral cortex (New York, N.Y. : 1991)2015
The impact of development and sensory deprivation on dendritic protrusions in the mouse barrel cortex.
Article in Cerebral cortex (New York, N.Y. : 1991), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 30 citations in OpenAlex.
- Cortical functional connectivity in mouse models of early blindness: enucleation vs. anophthalmia.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- [Research progress on the mechanism of auditory center remodeling and clinical intervention strategies in presbycusis].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2026Review
- Coordinated cellular architecture reveals weakened cortical structure-behavior coupling in normal aging.Frontiers in aging neuroscience · 2026Article
- X-ray diffraction reveals alterations in mouse somatosensory cortex following sensory deprivation.Journal of neuroscience methods · 2025Article
- Microglia-mediated inflammation and synaptic pruning contribute to sleep deprivation-induced mania in a sex-specific manner.Translational psychiatry · 2025Article
- Behavioral adaptations after unilateral whisker denervation.Behavioural brain research · 2025Article
- Astrocyte Modulation of Synaptic Plasticity Mediated by Activity-Dependent Sonic Hedgehog Signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Astrocyte modulation of synaptic plasticity mediated by activity-dependent Sonic hedgehog signaling.bioRxiv : the preprint server for biology · 2024Article
- Mechanisms governing activity-dependent synaptic pruning in the developing mammalian CNS.Nature reviews. Neuroscience · 2021Review
- Sensory Experience as a Regulator of Structural Plasticity in the Developing Whisker-to-Barrel System.Frontiers in cellular neuroscience · 2021Article
- Development and sensory experience dependent regulation of microglia in barrel cortex.The Journal of comparative neurology · 2020Article
- Early Sensory Loss Alters the Dendritic Branching and Spine Density of Supragranular Pyramidal Neurons in Rodent Primary Sensory Cortices.Frontiers in neural circuits · 2019Article
- Postnatal Ablation of Synaptic Retinoic Acid Signaling Impairs Cortical Information Processing and Sensory Discrimination in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Oligodendrocyte- and Neuron-Specific Nogo-A Restrict Dendritic Branching and Spine Density in the Adult Mouse Motor Cortex.Cerebral cortex (New York, N.Y. : 1991) · 2018Article
- Dendritic structural plasticity and neuropsychiatric disease.Nature reviews. Neuroscience · 2018Review
- Alpha-synuclein overexpression in the olfactory bulb initiates prodromal symptoms and pathology of Parkinson's disease.Translational neurodegeneration · 2018Article
- Pyramidal Neurons in Different Cortical Layers Exhibit Distinct Dynamics and Plasticity of Apical Dendritic Spines.Frontiers in neural circuits · 2017Article
- Oxytocin is implicated in social memory deficits induced by early sensory deprivation in mice.Molecular brain · 2016Article
- Opposing Effects of Neuronal Activity on Structural Plasticity.Frontiers in neuroanatomy · 2016Review
- Alterations in functional thalamocortical connectivity following neonatal whisker trimming with adult regrowth.Journal of neurophysiology · 2015Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Dendritic protrusions (spines and filopodia) are structural indicators of synapses that have been linked to neuronal learning and memory through their morphological alterations induced by development and experienced-dependent activities. Although previous studies have demonstrated that depriving sensory experience leads to structural changes in neocortical organization, the more subtle effects on dendritic protrusions remain unclear, mostly due to focus on only one specific cell type and/or age of manipulation. Here, we show that sensory deprivation induced by whisker trimming influences the dendritic protrusions of basilar dendrites located in thalamocortical recipient lamina (IV and VI) of the mouse barrel cortex in a layer-specific manner. Following 1 month of whisker trimming after birth, the density of dendritic protrusions increased in layer IV, but decreased in layer VI. Whisker regrowth for 1 month returned protrusion densities to comparable level of age-matched controls in layer VI, but not in layer IV. In adults, chronic sensory deprivation led to an increase in protrusion densities in layer IV, but not in layer VI. In addition, chronic pharmacological blockade of N-methyl-d-aspartate receptors (NMDARs) increased protrusion density in both layers IV and VI, which returned to the control level after 1 month of drug withdrawal. Our data reveal that different cortical layers respond to chronic sensory deprivation in different ways, with more pronounced effects during developmental critical periods than adulthood. We also show that chronically blocking NMDARs activity during developmental critical period also influences the protrusion density and morphology in the cerebral cortex.
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