ArticleJournal of comparative physiology. B, Biochemical, systemic, and environmental physiology2014
Substrate-specific changes in mitochondrial respiration in skeletal and cardiac muscle of hibernating thirteen-lined ground squirrels.
Article in Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 33 citations in OpenAlex.
- Arousal from hibernation increases blood oxygen saturation in 13-lined ground squirrels.The Journal of experimental biology · 2025Article
- Weakened Contractile Performance and Mitochondrial Respiratory Complex Activity in Skeletal Muscle Improve during Interbout Arousal in Hibernating Daurian Ground Squirrel,International journal of molecular sciences · 2023Article
- Metabolic rate increases with acclimation temperature and is associated with mitochondrial function in some tissues of threespine stickleback.The Journal of experimental biology · 2022Article
- Article
- Suppression of mitochondrial respiration by hydrogen sulfide in hibernating 13-lined ground squirrels.Free radical biology & medicine · 2021Article
- Body Protein Sparing in Hibernators: A Source for Biomedical Innovation.Frontiers in physiology · 2021Review
- Cytoprotection by a naturally occurring variant of ATP5G1 in Arctic ground squirrel neural progenitor cells.eLife · 2020Article
- Hypothermic oxygenated perfusion protects from mitochondrial injury before liver transplantation.EBioMedicine · 2020Article
- Changes in the phosphoproteome of brown adipose tissue during hibernation in the ground squirrel,Physiological genomics · 2017Article
- Reversible temperature-dependent differences in brown adipose tissue respiration during torpor in a mammalian hibernator.American journal of physiology. Regulatory, integrative and comparative physiology · 2017Article
- Enhanced oxidative capacity of ground squirrel brain mitochondria during hibernation.American journal of physiology. Regulatory, integrative and comparative physiology · 2017Article
- Proteomic Profiling Reveals Adaptive Responses to Surgical Myocardial Ischemia-Reperfusion in Hibernating Arctic Ground Squirrels Compared to Rats.Anesthesiology · 2016Article
- Role of AMP-activated protein kinase in metabolic depression in animals.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2016Review
- Saponin-permeabilization is not a viable alternative to isolated mitochondria for assessing oxidative metabolism in hibernation.Biology open · 2015Article
- Organ protective mechanisms common to extremes of physiology: a window through hibernation biology.Integrative and comparative biology · 2014Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During torpor, the metabolic rate (MR) of thirteen-lined ground squirrels (Ictidomys tridecemlineatus) is considerably lower relative to euthermia, resulting in part from temperature-independent mitochondrial metabolic suppression in liver and skeletal muscle, which together account for ~40% of basal MR. Although heart accounts for very little (<0.5%) of basal MR, in the present study, we showed that respiration rates were decreased up to 60% during torpor in both subsarcolemmal (SS) and intermyofibrillar (IM) mitochondria from cardiac muscle. We further demonstrated pronounced seasonal (summer vs. winter [i.e., interbout] euthermia) changes in respiration rates in both mitochondrial subpopulations in this tissue, consistent with a shift in fuel use away from carbohydrates and proteins and towards fatty acids and ketones. By contrast, these seasonal changes in respiration rates were not observed in either SS or IM mitochondria isolated from hind limb skeletal muscle. Both populations of skeletal muscle mitochondria, however, did exhibit metabolic suppression during torpor, and this suppression was 2- to 3-fold greater in IM mitochondria, which provide ATP for Ca(2+)- and myosin ATPases, the activities of which are likely quite low in skeletal muscle during torpor because animals are immobile. Finally, these changes in mitochondrial respiration rates were still evident when standardized to citrate synthase activity rather than to total mitochondrial protein.
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