Evidence map›Paper›PMID 24408534›Full record

ReviewCurrent allergy and asthma reports2014

Targeting the molecular and cellular interactions of the bone marrow niche in immunologic disease.

Jaime M Brozowski, Matthew J Billard, Teresa K Tarrant

Abstract readReview
In one paragraph

Review in Current allergy and asthma reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jaime M BrozowskiDepartment of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC, 27599, USA, Jaime_brozowski@med.unc.edu.
Matthew J Billard
Teresa K Tarrant

Funding

Modeling Lymphocyte Chemokine Receptor Dynamics and Polarization SignalsK01AI091863 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BILLARD, MATTHEW JOHN · 2012 to 2016
$423k
G protein-coupled receptor kinase 3 regulation of leukocyte function in inflammatR03AR059286 · NIAMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI TARRANT, TERESA KATHLEEN · 2011 to 2013
$218k
NIAID NIH HHS K01 AI091863NIAID NIH HHS K01AI091863NIAMS NIH HHS R03 AR059286NIAMS NIH HHS R03AR059286
6 · The paper itself

Abstract

Recent investigations have expanded our knowledge of the regulatory bone marrow (BM) niche, which is critical in maintaining and directing hematopoietic stem cell (HSC) self-renewal and differentiation. Osteoblasts, mesenchymal stem cells (MSCs), and CXCL12-abundant reticular (CAR) cells are niche components in close association with HSCs and have been more clearly defined in immune cell function and homeostasis. Importantly, cellular inhabitants of the BM niche signal through G protein-coupled surface receptors (GPCRs) for various appropriate immune functions. In this article, recent literature on BM niche inhabitants (HSCs, osteoblasts, MSCs, CAR cells) and their GPCR mechanistic interactions are reviewed for better understanding of the BM cells involved in immune development, immunologic disease, and current immune reconstitution therapies.

Indexed as

AnimalsBone MarrowBone Marrow CellsCell CommunicationHematopoietic Stem CellsHumansImmune System DiseasesMesenchymal Stem Cells

Identifiers

PMID24408534
PMCPMC3932436

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.