ArticleScience (New York, N.Y.)2014
Progenitor outgrowth from the niche in Drosophila trachea is guided by FGF from decaying branches.
Article in Science (New York, N.Y.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed.
- A single-cell atlas of alternative wing development in two hemipteran species.Nature communications · 2026Article
- Article
- Single-nucleus transcriptomics of wing sexual dimorphism and scale cell specialization in sulphur butterflies.PLoS biology · 2025Article
- A single-cell atlas of Drosophila trachea reveals glycosylation-mediated Notch signaling in cell fate specification.Nature communications · 2024Article
- Lateral adherens junctions mediate a supracellular actomyosin cortex in drosophila trachea.iScience · 2023Article
- Differentiation signals from glia are fine-tuned to set neuronal numbers during development.eLife · 2022Article
- Metabolic control of progenitor cell propagation during Drosophila tracheal remodeling.Nature communications · 2022Article
- Airway remodeling: TheFrontiers in allergy · 2022Review
- Article
- Role and mechanisms of autophagy in lung metabolism and repair.Cellular and molecular life sciences : CMLS · 2021Review
- Article
- Macrophages and Their Organ Locations Shape Each Other in Development and Homeostasis - AFrontiers in cell and developmental biology · 2021Review
- Stem cell niche exit ineLife · 2020Article
- Dual role of FGF in proliferation and endoreplication of Drosophila tracheal adult progenitor cells.Journal of molecular cell biology · 2020Article
- Progenitor targeting by adult stem cells in Ciona homeostasis, injury, and regeneration.Developmental biology · 2019Article
- Lung regeneration by multipotent stem cells residing at the bronchioalveolar-duct junction.Nature genetics · 2019Article
- Development and Function of theGenetics · 2018Review
- Visualizing Dynamics of Cell Signaling In Vivo with a Phase Separation-Based Kinase Reporter.Molecular cell · 2018Article
- Unique patterns of organization and migration of FGF-expressing cells during Drosophila morphogenesis.Developmental biology · 2017Article
- New Twists in Drosophila Cell Signaling.The Journal of biological chemistry · 2016Review
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Abstract
Although there has been progress identifying adult stem and progenitor cells and the signals that control their proliferation and differentiation, little is known about the substrates and signals that guide them out of their niche. By examining Drosophila tracheal outgrowth during metamorphosis, we show that progenitors follow a stereotyped path out of the niche, tracking along a subset of tracheal branches destined for destruction. The embryonic tracheal inducer branchless FGF (fibroblast growth factor) is expressed dynamically just ahead of progenitor outgrowth in decaying branches. Knockdown of branchless abrogates progenitor outgrowth, whereas misexpression redirects it. Thus, reactivation of an embryonic tracheal inducer in decaying branches directs outgrowth of progenitors that replace them. This explains how the structure of a newly generated tissue is coordinated with that of the old.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.