ArticleObesity surgery2014
Metabolic, behavioral, and reproductive effects of vertical sleeve gastrectomy in an obese rat model of polycystic ovary syndrome.
Article in Obesity surgery, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Metabolic dysfunction in polycystic ovary syndrome: Pathogenic role of androgen excess and potential therapeutic strategies.Molecular metabolism · 2020Pooled it
- Curbing Obesity from One Generation to Another: the Effects of Bariatric Surgery on the In Utero Environment and Beyond.Reproductive sciences (Thousand Oaks, Calif.) · 2020Review
- Article
- Effect of Sleeve Gastrectomy on Kisspeptin Expression in the Hypothalamus of Rats with Polycystic Ovary Syndrome.Obesity (Silver Spring, Md.) · 2020Article
- Immunophenotypic Profiles in Polycystic Ovary Syndrome.Mediators of inflammation · 2020Review
- Immunophenotypic profile of leukocytes in hyperandrogenemic female rat an animal model of polycystic ovary syndrome.Life sciences · 2019Article
- Sleeve Gastrectomy for Obesity in Polycystic Ovarian Syndrome: a Pilot Study Evaluating Weight Loss and Fertility Outcomes.Obesity surgery · 2019Article
- Deficiency of Gpr1 improves steroid hormone abnormality in hyperandrogenized mice.Reproductive biology and endocrinology : RB&E · 2018Article
- Vertical sleeve gastrectomy improves indices of metabolic disease in rodent model of surgical menopause.Menopause (New York, N.Y.) · 2017Article
- Diet-induced obesity exacerbates metabolic and behavioral effects of polycystic ovary syndrome in a rodent model.American journal of physiology. Endocrinology and metabolism · 2015Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
backgroundPolycystic ovary syndrome (PCOS) is the most common endocrinopathy affecting women of reproductive age. Its clinical expression is diverse, including metabolic, behavioral, and reproductive effects, with many affected by obesity and decreased quality of life. Women with PCOS who have undergone surgically induced weight loss have reported tremendous benefit, not only with weight loss, but also improvement of hyperandrogenism and menstrual cyclicity.
methodsIn a rat model of PCOS achieved via chronic administration of dihydrotestosterone (DHT) exposure, we investigated the ability of bariatric surgery, specifically vertical sleeve gastrectomy (VSG), to ameliorate the metabolic, behavioral, and reproductive abnormalities invoked by this PCOS model.
resultsWe found that DHT treatment combined with exposure to a high-fat diet resulted in increased body weight and body fat, impaired fasting glucose, hirsutism, anxiety, and irregular cycles. VSG resulted in reduced food intake, body weight, and adiposity with improved fasting glucose and triglycerides. VSG induced lower basal corticosterone levels and attenuated stress responsivity. Once the DHT levels decreased to normal, regular estrous cyclicity was also restored.
conclusionsVSG, therefore, improved PCOS manifestations in a comprehensive manner and may represent a potential therapeutic approach for specific aspects of PCOS.
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