ArticlePsychopharmacology2014
Alcohol calibration of tests measuring skills related to car driving.
Article in Psychopharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 51 citations in OpenAlex.
- Driving performance in the morning after bedtime vornorexant administration: A randomized clinical trial using a driving simulator.Psychiatry and clinical neurosciences · 2025Trial
- Nighttime safety of daridorexant: Evaluation of responsiveness to an external noise stimulus, postural stability, walking, and cognitive function.Journal of psychopharmacology (Oxford, England) · 2025Trial
- Effects of alcohol intoxication on driving performance, confidence in driving ability, and psychomotor function: a randomized, double-blind, placebo-controlled study.Psychopharmacology · 2022Trial
- Deterioration of binocular vision after alcohol intake influences driving performance.Scientific reports · 2021Trial
- A clinical trial on the acute effects of methadone and buprenorphine on actual driving and cognitive function of healthy volunteers.British journal of clinical pharmacology · 2019Trial
- Comparing the effects of oxazepam and diazepam in actual highway driving and neurocognitive test performance: a validation study.Psychopharmacology · 2018Trial
- On-the-road driving performance the morning after bedtime use of suvorexant 15 and 30 mg in healthy elderly.Psychopharmacology · 2016Trial
- Trial
- Driving performance under alcohol in simulated representative driving tasks: an alcohol calibration study for impairments related to medicinal drugs.Journal of clinical psychopharmacology · 2015Trial
- Evaluating and Determining the Effects of Psychotropic Drugs on Motor Vehicle Driving Performance: Key Considerations of the Japanese Guideline and Criteria for Clinical Implementation of Evidence.Neuropsychopharmacology reports · 2026Review
- The impact of alcohol intoxication on extended vigilance and rest-break recovery.Attention, perception & psychophysics · 2025Article
- No significant gender differences in driving-related skills following alcohol mixed with energy drinks during an experimental binge-drinking episode.Frontiers in pharmacology · 2025Article
- Effects of alcohol consumption on driving performance in the presence of interocular differences simulated by filters.Scientific reports · 2023Article
- Comparing objective wakefulness and vigilance tests to on-the-road driving performance in narcolepsy and idiopathic hypersomnia.Journal of sleep research · 2022Article
- Effects of High-Potency Cannabis on Psychomotor Performance in Frequent Cannabis Users.Cannabis and cannabinoid research · 2022Article
- A Comparison of Acute Neurocognitive and Psychotomimetic Effects of a Synthetic Cannabinoid and Natural Cannabis at Psychotropic Dose Equivalence.Frontiers in psychiatry · 2022Article
- Supervision of a self-driving vehicle unmasks latent sleepiness relative to manually controlled driving.Scientific reports · 2021Article
- Assessment of cognitive and psychomotor impairment, subjective effects, and blood THC concentrations following acute administration of oral and vaporized cannabis.Journal of psychopharmacology (Oxford, England) · 2021Article
- Driving performance and neurocognitive skills of long-term users of sedating antidepressants.Human psychopharmacology · 2021Article
- From bench to bar side: Evaluating theOpen life sciences · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleMedication and illicit drugs can have detrimental side effects which impair driving performance. A drug's impairing potential should be determined by well-validated, reliable, and sensitive tests and ideally be calibrated by benchmark drugs and doses. To date, no consensus has been reached on the issue of which psychometric tests are best suited for initial screening of a drug's driving impairment potential.
objectiveThe aim of this alcohol calibration study is to determine which performance tests are useful to measure drug-induced impairment. The effects of alcohol are used to compare the psychometric quality between tests and as benchmark to quantify performance changes in each test associated with potentially impairing drug effects.
methodsTwenty-four healthy volunteers participated in a double-blind, four-way crossover study. Treatments were placebo and three different doses of alcohol leading to blood alcohol concentrations (BACs) of 0.2, 0.5, and 0.8 g/L.
resultsMain effects of alcohol were found in most tests. Compared with placebo, performance in the Divided Attention Test (DAT) was significantly impaired after all alcohol doses and performance in the Psychomotor Vigilance Test (PVT) and the Balance Test was impaired with a BAC of 0.5 and 0.8 g/L. The largest effect sizes were found on postural balance with eyes open and mean reaction time in the divided attention and the psychomotor vigilance test.
conclusionsThe preferable tests for initial screening are the DAT and the PVT, as these tests were most sensitive to the impairing effects of alcohol and being considerably valid in assessing potential driving impairment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.